Experimental and Theoretical Mass Spectrometric Quantification of Non-Covalent Interactions in High Order Homogeneous Self-Associates of Nucleobases and Nucleosides

It is widely accepted that the quadruplex, representing a supramolecular self-aggregate of guanine (G) containing recurrent units of four noncovalent interacting nucleobases (NBs) and one monovalent cation in DNA and RNA, has been associated with genome instability, transcription and replication of living cells. This line of inquiry has also evidenced experimentally associates such as quartets of ...