p53: Structure, Functions and Role in Disease

p53: Structure, Functions and Role in Disease discusses the role of p53 dysregulation in different hematologic neoplasms defined by the current WHO classification. The prevalence of p53 aberration, mechanisms of p53 inactivation, regulation of p53 signaling pathway, and prognostic implications of p53 dysfunction in different hematologic malignancies are reviewed. The authors also discuss the preva...