Starling's Law of The Heart Revisited

H. E. D. J. TER KEURS & M. I. M. NOBLE The "Starling''s Law of the Heart" and "The Frank-Starling Mechanism" have long been the cornerstone of cardiac mechanical physiology. It is often forgotten that Frank and Starling carried out fundamentally different exper­ iments. Frankl measured the isovolumic pressure developed by frog heart at different volumes. He therefore discovered the pressure-volume...