Sunitinib: Mechanisms, Interactions and Side Effects

Tyrosine kinase inhibitors are used to treat patients with advanced thyroid cancers. Sunitinib (SU11248) is an oral small-molecule, oxindol derivative, multi-targeted tyrosine kinase inhibitor that inhibits receptors for platelet-derived growth factor and vascular endothelial growth factor receptors, growth factor receptor, fms-related tyrosine kinase 3, RET oncogene and a multitargeted tyrosine-k...