Thyroid Hormone Disruption and Neurodevelopment

Thyroid hormone plays an important role in development and functional maintenance in the central nervous system.  Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans.  However, the molecular mechanism of thyroid hormone action has not yet been fully understood.  Thyroid hormone action in the brain may be disrupted under vari...