Molecular Biology of Bacterial Virus Systems

The fact that none of the known DNA polymerases is able to initiate DNA chains but only to elongate from a free 3'' -OH group raises the problem of how replication is initiated, both at the replication origin and on Okazaki frag­ ments. It was first shown by A. KORNBERG et al. that a general mechanism to initiate replication is through the formation of an RNA primer catalyzed by RNA polymerases or...