Shh and Gli Signalling in Development

he hedgehog signalling pathway is highly conserved and seen in organisms ranging from Drosophila to humans. This pathway is Tcritical in determining cell fate decisions in a variety of different cell types. There are several vertebrate analogues of the Drosophila hedgehog protein of which the most widely studied is Sonic hedgehog (Shh). Shh signalling classically involves the Gli family of zinc-fm...