Although Prader-Willi syndrome was first described 35 years ago, it was following detection of an interstitial chromosome 15q deletion in some affected patients ten years ago that it became a major focus of multidisciplinary scientific interest.
An introductory discussion of basic chromosome structure andfunction preceeds the main text on the application ofcytogenetic approaches to the analysis of the manipulationof both the genetic make-up and the genetic transmissionsystem of plant breeding material.
In retrospect, the range of topics covered in this monograph, although forming a coherent ensemble, is so extensive that a detailed discussion could easily extend to three or four times the current length.
The majority of scientists interested in fertilization and early developmental processes will undoubtably have encountered the works of Alberto Monroy at some time in their careers.
Taxonomy is fundamental to understanding the variety of lifeforms, and exciting expansions in molecular biology are re-volutionising the obtained data.
In the field of Hodgkin's lymphoma, many new data have been collected during the last decade both on the cell of origin of this disease and on more effective therapies to cure the majority of pa- tients even in the advanced stages.
A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression.
Activation by and desensitization to signals originating from the environment is common in all organisms, ranging from prokaryotes to higher eukaryotes.
This book is a collection of papers presented at a NATO Advanced Research Workshop on "e;Biology and Molecular Biology of Plant-Pathogen Interactions"e; which was held at Dillington College, Ilminster, UK, 1-6 September 1985.
In 1966, a paper entitled "e;On the formation of a novel adenylylic compound by enzymatic extracts of liver nuclei"e; from Paul Mandel's laboratory in Strasbourg, France, planted the seed for a rapidly growing new field of biological research focusing on ADP-ribosylation reactions.
The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis.
Malignant growth of cells is often characterized by disorganization of tissue structure, abnormal blood vessel development, and insuffi- cient vascular supply.
Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity.
The "e;functional"e; in the title of this book not only reflects my personal bias about neuroanatomy in brain research, it is also the gist of many chapters which describe sophisticated ways to resolve structures and interpret them as dynamic entities.
The techniques of plant organ, tissue, and cell culture concentrated on reproducibility, simplicity and accu- are now established in many research laboratories racy with sufficient illustration to make all mani- throughout the world and are being used in numerous pulations clear.
In late 1971 we were involved in a study of the interaction of radiation with matter and were trying to use measurements of radiation fluorescence in biological molecules to indicate how radiation affected living cells.
Since the Russian edition of this book was published in 1975 many new research works have appeared which have made necessary some additions for the English edition, to reflect progress in molecular developmental genetics.
The cells of the immune system generate a large variety of binding sites which differ in their binding specificities and can therefore react specifically with a large variety of ligands.
Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism.
In the continuing quest to explore structure and to relate struc- tural organization to functional significance, the scientist has developed a vast array of microscopes.