The sequencing of the human genome and subsequent elucidation of the molecular pathways that are important in the pathology of disease have provided unprecedented opportunities for the development of new therapeutics.
The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of verte- brates, along with many other systems involved in the in- tegrated survival of the organism.
This detailed book collects standard techniques and cutting-edge methods that are frequently used by the research community studying the fungus Trichoderma reesei.
Demonstrating the interdisciplinary nature of modern glycosciences, this volume covers research in the fields of polysaccharides and small carbohydrates from the synthetic and structural viewpoints, with applications ranging from biology to the bioeconomy.
How life originated from the inanimate mixture of organic and inorganic compounds on the priomordial earth remains one of the great unknowns in science.
Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics along with the ability to selectively knockout genes of interest has greatly advanced our understanding of maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy.
The so-called postgenomic research era has now been launched, and the field of gly- cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo.
This volume provides new technologies on NRPSs and related carrier protein dependent synthases, including polyketide synthases (PKS) and fatty acid synthases (FAS).
This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control.
The range of nanomaterial applications has expanded recently from catalysis, electronics, and filtration to therapeutics, diagnostics, agriculture, and food because of unique properties and potentials of different nanoparticles and nanomaterials.
This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression.
This second edition volume expands on the previous edition with new chapters and updated discussions on the latest advancements in the development and practice of metabolic phenotyping.
Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity.
This second edition volume presents new and updated protocols on comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations.
This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales.
The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids (fats) and the lipid-bilayer component of cell membranes.
For nearly 50 years, pest control was mostly based on broad-spectrum conv- tional insecticides such as organochlorines, organophosphates, carbamates and pyrethroids.
This book presents the structure of the main toxins of aquatic origin, their distribution, producing species and vectors, their mechanisms of action, the clinical aspects of envenomation in humans, their effects in laboratory or wild animals, their toxicokinetic properties, including the relevant treatment, detection methods and regulatory aspects for management.
Thissecond edition offers a comprehensive overview of the physiological functionsof vertebrate kidneys from a comparative viewpoint, with particular emphasis onnonmammalian vertebrates.
This volume explores techniques used to detect lipids attached to proteins, to analyze the function of lipid modifications, and to characterize the enzymes that add and remove lipids from proteins.
The development of the life sciences may be said to have effected a gradual transition from a more or less intuitive prescientific approach based on crude observation, via a more refined type of observation to experimentation and hence to the level of formal theories.
Exploring current themes in modern computational and membrane protein biophysics, this book presents a comprehensive account of the fundamental principles underlying different methods and techniques used to describe the intriguing mechanisms by which membrane proteins function.
