Oncology

Since cytotoxic drugs were first developed, their damaging effects on bone marrow have attracted considerable interest.

Transplantation of syngeneic (donor is a monozygous twin) or allogeneic (donor is an HLA-identical sibling) marrow provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity.

Attempts to influence survival of patients with colorectal cancer (CRC) by adjuvant chemotherapy are limited by the variability of survival in different prognostic groups [4] and the paucity of drugs that have shown activity in the advanced disease [10].

The purpose of this monograph is to address the basic mecha- nisms for organizing trials.

In February 1980 the Royal College of Radiologists, London, held its Second Symposium on Clinical Oncology.

The Analog Potential in Cancer Chemotherapy in the United States and Japan S.

Progress in basic research has made it necessary to redetermine the possibility of classic endocrine therapy for the treatment of patients with breast cancer.

The subject of this publication, thyroid cancer, was the topic chosen for the First Symposium on Clinical Oncology, orga- nized by the Royal College of Radiologists, London, on 26 and 27 January 1979.

P.

We have studied 24 cases of secondarily leukemic (stage V) lymphosarcoma (LS), 31 cases of "e;d'emblee"e; leukemic LS, and ten cases of lymphoid leukemic neoplasias transitional between "e;d'emblee"e; leukemic LS and chronic lymphocytic leukemia (eLL).

Tactics is the art of combining the action of troops or the proper means of different arms with the object of obtaining the maximum success at combat.

The cloning of hemopoietic cells in semisolid medium began some 12 years ago, and when colonies of T = and B = lymphocytes were grown by several groups last year, the last major subclasses of hemopoietic cells had been successfully cultured in vitro.

E.

A.

Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism.

Fresh living Bacillus Calmette-Guerin (BeG), injected i.

Cancer in childhood is a rare disease, but for many reasons attracts interest out of proportion to its frequency.

I would like to thank all my co-workers who have collaborated with me, from 1963 until now, in biological and clinical research in the field of cancer active immunotherapy, of its immuno- prevention and immunorestoration.

Bone Tumors - A Challenge for Cooperation E.

When I was asked by the Cancer Teaching Committee of the University of Chicago to set up a Symposium on Brain Tumors, I welcomed the opportunity to do so.

G.

K.

Interest in the general field of tumor immunology has grown phenomenally in recent years.

The geography of medicine is a classical subject that can be studied wherever medicine is practised and the population counted.

The contributions in this book were originally presented at the workshop "e;Research and Clinical Application of Isolated Liver Perfusion for Hepatic Tumors"e; held on 28 February to 1 March 1997 in Hanover, Germany.

Several compounds are associated with experimentally induced neoplasms in the urinary systems, and especially the kidneys, of laboratory animals.

Oral Pathology as part of the Head and Neck Pathology is an interdisciplinary field of science.

Der Stellenwert von bisher eingesetzten und neuentwickelten nuklearmedizinischen Verfahren bei der Diagnostik des Mammakarzinoms und dessen Metastasen ist Thema dieses Buches.

Almost a century ago Paul Ehrlich introduced the "e;magic bullet"e; concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity.

Primary mediastinal tumors are relatively rare.

We often hear physicians, health care professionals, poli- ticians, and patient advocates that "e;nothing has happened in the treatment of breast cancer,"e; since patients with breast cancer, the most frequent neoplastic condition in women in industrialized countries, are continuing to suffer relapse and succumb to this dreadful disease!

During the last years much attention has been given to the investigation of the roles of specific growth modulators acting on liver cell populations.

The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer.

All epidemiological data predict an endemic rise of prostate cancer in populations with a high proportion of elderly people, leading to a major health problem.

Presented here are recent data on the mechanisms of action of different dusts and fibres of industrial interest.