In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies.
Quantitative Methodologies and Process for Safety Monitoring and Ongoing Benefit Risk Evaluation provides a comprehensive coverage on safety monitoring methodologies, covering both global trends and regional initiatives.
With a DVD of color figures, Clustering in Bioinformatics and Drug Discovery provides an expert guide on extracting the most pertinent information from pharmaceutical and biomedical data.
Signal Processing for Neuroscientists, Second Edition provides an introduction to signal processing and modeling for those with a modest understanding of algebra, trigonometry and calculus.
A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible.
Recent Progress in Hormone Research, Volume 30 presents the proceedings of the 1973 Laurentian Hormone Conference held at Mont Tremblant, Province of Quebec, Canada on August 26-31, 1973.
Understanding Biology Using Peptides: Proceedings of the 19th American Peptide Symposium highlights many of the recent developments in peptide science, with a particular emphasis on how these advances are being applied to basic problems in biology and medicine.
The management of clinical data, from its collection during a trial to its extraction for analysis, has become critical in preparing a regulatory submission and obtaining approval to market a treatment.
The Practice of Clinical Engineering deals with clinical engineering, its educational requirements, the requirements for accreditation, and practice, including legislation and liability.
That residues of pesticide and other contaminants in the total environment are of concern to everyone everywhere is attested by the reception accorded previous volumes of "e;Residue Reviews"e; and by the gratifying enthusiasm, sincerity, and efforts shown by all the in- dividuals from whom manuscripts have been solicited.
This book provides an overview of Data Monitoring Committees(DMC) - what was done in the past, what is currently being done, and thoughts on improvements for the future.
In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults.
Modern Trends in Physiological Sciences, Volume 32: Human Afflictions and Chromosomal Aberrations presents the study of the links between chromosome aberrations and physical and mental congenital anomalies.
This book provides a comprehensive reference guide to plant-derived antioxidants, their beneficial effects, mechanisms of action, and role in disease prevention and improving general health (anti-ageing effect).
The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models.
With the critical role of statistics in the design, conduct, analysis and reporting of clinical trials or observational studies intended for regulatory purposes, numerous guidelines have been issued by regulatory authorities around the world focusing on statistical issues related to drug development.
The 1st edition of Error Reduction and Prevention in Surgical Pathology was an opportunity to pull together into one place all the ideas related to errors in surgical pathology and to organize a discipline in error reduction.
Positive deviance – identifying those who demonstrate exceptional performance and investigating how they achieve this – has untapped potential in healthcare improvement.
The Third Edition of Arlene Fink’s Evaluation Fundamentals teaches the basic concepts and vocabulary necessary to do program evaluations and review the quality of evaluation research to make informed decisions about methods and outcomes to meet scientific and community needs.
Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread.
Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction.
"e;The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies.
Endocrine Pathology: Differential Diagnosis and Molecular Advances, Second Edition provides detailed coverage of endocrine pathology with extensive discussion of the differential diagnosis as well as presentation of molecular pathobiology of the major endocrine organs.
Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens.
That residues of pesticide and other "e;foreign"e; chemicals in foodstuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of "e;Residue Reviews"e; and by the gratifying en- thusiasm, sincerity, and efforts shown by all the individuals from whom manuscripts have been solicited.
The US Food and Drug Administration's Report to the Nation in 2004 and 2005 indicated that one of the top reasons for drug recall was that stability data did not support existing expiration dates.
Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature).
Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety.
