Medical research

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies.

Lynch syndrome (LS) is the most common cause of inherited colorectal cancer, a disease with a high mortality rate.

In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors.

This entry in the series Pediatric Cancer offers comprehensive information on a variety of cancers, concentrating on brain tumors, the most common solid tumors and the leading cause of cancer-related mortality in children.

This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle.

This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis.

Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects.

Scorpions have fascinated humans for a long time, first and foremost because of the harm the sting of a few species could cause but also due to their unique natural history and for the many biologically active compounds found in their venoms.

This volume provides an overview of microbial toxins from diverse bacterial and fungal origins.

Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized.

This book is designed to collect and review the research covering main directions in investigations of aromatic nitroso compounds in last decades, and to present both, the academic aspects of this chemistry, as well as the open field of its applicability.

This book will bring together leading international experts to discuss recent advances in basic scientific knowledge regarding the regulation of presynaptic Ca2+ channels.

This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells.

Cognitive enhancement is the use of drugs, biotechnological strategies or other means by healthy individuals aiming at the improvement of cognitive functions such as vigilance, concentration or memory without any medical need.

There has been a dramatic increase in knowledge of tight junctions in the past decade.

This book is part of a series dedicated to recent advances on preventive, predictive and personalised medicine (PPPM).

This book is intended to provide up-to-date and emerging information in the field of diabetes mellitus with a focus on preventive, predictive and personalized medicine.

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The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection.

This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation.

The existence of life at high temperatures is quiet fascinating.

Methods of proteomics have been shown to be powerful tools in search of target proteins - proteins that respond in cells to an internal or an external stimulus.

This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases.

The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy.

Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments' side effects.

Machine learning is a novel discipline concerned with the analysis of large and multiple variables data.

This book contains 14 original review chapters each yielding new, exciting and intriguing data about the emerging understanding of nucleolar structure and function in normal, stressed and diseased cells.

"e;Bioinformatics of Human Proteomics"e; discusses the development of methods, techniques and applications in the field of protein bioinformatics, an important direction in bioinformatics.

Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body.

Although monotherapy is generally recommended as the treatment of choice, treatment resistance of patients with psychosis, cognitive, mood and anxiety disorders represents a significant clinical problem.

Although monotherapy is generally recommended as the treatment of choice, treatment resistance of patients with psychosis, cognitive, mood and anxiety disorders represents a significant clinical problem.

This book, written by one of the leaders in the field of the neurosciences, will give an explanation of the symptoms and eventual untimely suicide of one of literatures greatest authors; Virginia Woolf.

The field of regenerative medicine has developed rapidly over the past 20 years with the advent of molecular and cellular techniques.

Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors.

This book continues as volume 5 of a multicompendium on Edible Medicinal and Non-Medicinal Plants.

This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs.

This book continues as volume 6 of a multi-compendium on Edible Medicinal and Non-Medicinal Plants.

This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours.

Humans are diurnal organisms whose biological clock and temporal organization depend on natural light/dark cycles.

Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development.

The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans' susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases.

The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology.

Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain.

Tetraspanin proteins have recently emerged as a new class of modulators of various processes involving cell surface receptors, including cell migration and invasion, host immune responses, cell-cell fusion, and viral infection.

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This book is designed to be a long term career reference.

The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system.

This book contains a collection of papers that were presented at the IUTAM Symposiumon "e;Computer Models in Biomechanics: From Nano to Macro"e; held at Stanford University, California, USA, from August 29 to September 2, 2011.

"e;HPV and Cancer"e; is a concise read that covers all aspects of the Human Papilloma Virus as it relates to human cancers.

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer's disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer's disease.