Medical genetics

Biological Aging: Methods and Protocols investigates the various processes that are affected by the age of an organism.

Since the publication of the first edition, the number of unique heritable mtDNA mutations recognized as being associated with bioenergetic dysfunction, cell death and disease has grown.

Biolistic transfection represents a direct physical gene transfer approach in which nucleic acids are precipitated on biologically inert high-density microparticles (usually gold or tungsten) and delivered directly through cell walls and/or membranes into the nucleus of target cells by high-velocity acceleration using a ballistic device such as the gene gun.

The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes.

The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies.

Over the past twenty years, the development of chromatin immunoprecipitation, or ChIP, assays has immensely enhanced the biological significance of the multifaceted DNA-binding proteins.

In Nucleic Acid Chemistry: Methods and Protocols, expert researches in the field detail techniques and approaches for the detection of DNA and RNA.

Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data.

Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy.

After the generation of genome sequence data from a wide variety of plants, databases are filled with sequence information of genes with no known biological function, and while bioinformatics tools can help analyze genome sequences and predict gene structures, experimental approaches to discover gene functions need to be widely implemented.

The new genetic revolution is fuelled by Deep Sequencing (or Next Generation Sequencing) apparatuses which, in essence, read billions of nucleotides per reaction.

The numerous vital applications of complementary DNA (cDNA) technology have changed dramatically as the technology has advanced over recent years.

Protocols for Nucleic Acid Analysis by Non-radioactive Probes, Second Edition provides a firm background on the basic preparative protocols required for the analysis of nucleic acids by nonradioactive methods.

Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body.

The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells.

This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations.

Very Short Introductions: Brilliant, Sharp, Inspiring In this exploration of the concept of the gene, Jonathan Slack looks at the discovery, nature, and role of genes in both evolution and development.

This book provides a detailed overview of the latest developments in the rapidly evolving specialty of Neuro-Oncology arranged in approximately 500 questions arranged in multiple-choice and matching formats.

This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia.

Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years.

This volume explores and challenges the assumption that behavioral proclivities and pathologies are directly traceable to experience-an assumption that still widely dominates folk psychology as well as the perspective of many mental health practitioners.

This volume explores and challenges the assumption that behavioral proclivities and pathologies are directly traceable to experience-an assumption that still widely dominates folk psychology as well as the perspective of many mental health practitioners.

Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years.

This book entitled "e;Cancer Stem Cell Markers and Related Network Path-ways"e; is about cancer stem cell (CSC) markers and the molecular network pathways.

Brain tumors comprise about 5-9% of all human neoplasms; and interestingly the central nervous system (CNS) neoplasms are ranked among the most prevalent neoplasms of childhood as well.

Die Geschichte einer der mächtigsten und gefährlichsten Ideen der MenschheitMukherjee kreiert ein ambitioniertes und faszinierendes Panorama über den Versuch, das menschliche Genom zu entschlüsseln und in unser Erbgut einzugreifen.

The volume summarizes the most recent advances in our understanding of the mesentery and explains the how these are important in inflammation.

This volume provides protocols designed to study the function and the structure of diverse ribozymes.

Now in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype.

This book explores the interrelationship of genetics, the environment, or both, in the causation of three neurodevelopmental disorders: autism/autism spectrum disorder (ASD), fetal alcohol spectrum disorder (FASD), and cerebral palsy (CP).

This volume presents a comprehensive collection of detailed state-of-the-art protocols for gapmer-mediated RNA knockdown from leaders in the field.

Very Short Introductions: Brilliant, Sharp, Inspiring In this exploration of the concept of the gene, Jonathan Slack looks at the discovery, nature, and role of genes in both evolution and development.

Strategies or decisions aimed at affecting, in a manner considered to be positive, the genetic heritage of a child in the context of human reproduction are increasingly being accepted in contemporary society.

Get right to the source of your uniqueness!

The third edition of Craniofacial Embryogenetics and Development is dedicated to increased understanding of normal and abnormal orofacial development by integrating embryological development with its underlying genetic information.

From the Foreword by Candy Cooley, formerly Genetics Awareness Programme Lead at the NHS National Genetics and Genomics Education Centre: What a delight it is to read a book which takes complex scientific concepts and ensures they are understandable by all.

This book describes newborn screening as a public health program for the early detection of genetic disorders.

This book describes how obesity results from an imbalance between the intake of food energy and the expenditure of energy from physical activity and increases the risk of serious health problems including heart disease, stroke, osteoarthritis, and several types of cancer.

Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression.

This book presents work that has been conducted as part of the research project "e;Discourse on ethical questions of biomedicine"e; of the interdisciplinary Working Group Bioethics and Science Communication at the Max-Delbrueck-Center for Molecular Medicine (MDC)in Berlin-Buch, Germany.

Tough Test Questions?

Incorporate genomics into every applicable area of your clinical practice with this complete how-to guideA Doody's Core Title for 2024 & 2021!

Genetic approaches have revolutionized our understanding of the fundamental causes of human disease by permitting the identification of specific genes in which variation causes or contributes to susceptibility to, or protection from, disease.

This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide.

In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses.

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

Employing accessible language throughout, this book covers the history of psychiatric research, the current state-of-the art in psychiatric practice, the physiological systems affected by psychiatric illnesses, the whole-body nature of these diseases and the impact that this aspect has on emerging biomarker discoveries.

Should parents aim to make their children as normal as possible to increase their chances to "e;fit in"e;?

This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health.

This book examines in depth the evidence, clinical applications and potential cancer signatures in the circulation and discusses alterations in circulating cell-free nucleic acids, and circulating tumor DNA, as well as the epigenome, genome, transcriptome (coding and noncoding), proteome (both traditional serum proteins and proteomic profiles) and metabolome.