Medical genetics

This book is being planned as a tribute to Dr.

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics.

Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life.

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide.

Computer access is the only way to retrieve up-to-date sequences and this book shows researchers puzzled by the maze of URLs, sites, and searches how to use internet technology to find and analyze genetic data.

This is the first book in the field to address the underlying biological abnormalities of Dementia in Alzheimer's Disease (DAD) in people with Down syndrome.

The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs"e;Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists.

A comprehensive and authoritative compilation of up-to-date developments in stem cell research and its use in toxicology and medicine Presented by internationally recognized investigators in this exciting field of scientific research Provides an insight into the current trends and future directions of research in this rapidly developing new field A valuable and excellent source of authoritative and up-to-date information for researchers, toxicologists, drug industry, risk assessors and regulators in academia, industry and government

This textbook will support graduate students with learning materials rich in the basic concepts of stem cell biology, in its most widespread and updated perspective.

Genomic and Precision Medicine: Cardiovascular Disease, Third Edition, focuses on the applications of genome discovery on the broad spectrum of cardiovascular disorders.

Much research has focused on the basic cellular and molecular biological aspects of stem cells.

This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives.

This book reviews the recent research into biological aspects of suicide behavior and outlines each of the varied, recent approaches to prevent suicide.

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate.

Risk Factors for Cerebrovascular Disease and Stroke address the relationship of a wide variety of vascular risk factors in the spectrum of cerebrovascular diseases.

Knowing one's genetic disposition to a variety of diseases, including common chronic diseases, can benefit both the individual and society at large.

This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations.

Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry.

This is a comprehensive 2006 guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility.

Clear, understandable and concise with an accompanying internet guide, this is an unbeatable resource for learning, revision and staying up to date.

The "e;Progress in Cell Cycle Research"e; series is dedicated to serve as a collection of reviews on various aspects of the cell division cycle, with special emphasis on less studied aspects.

Congenital malformations are worldwide occurrences, they know no national borders, do not distinguish between races, ethnicities, rich or poor.

The only source on the subject to offer both an overview and a disease-based approach, this reference text spans the wide array of technical, methodological, regulatory, and ethical issues related to pharmacogenetics and stresses the impact of pharmacogenetic data on patient care and management.

A review of the clinical, genetic and pathophysiological features and treatment of neurological disorders caused by variants in two brain potassium channel genes (KCNQ2, KCNQ3).

Communicating with patients about genetic concepts is fraught with complications.

Autoimmune diseases are diverse and responsible for considerable morbidity.

Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data.

The Trouble with Twin Studies questions popular genetic explanations of human behavioral differences based upon the existing body of twin research.

Denis Noble Nearly a decade after completion of the first draft of the entire Human Genome sequence we are in a better position to assess the nature and the consequences of that heroic achievement, which can be seen as the culmination of the molecular biological revolution of the second half of the twentieth century.

The OMICs: Applications in Neuroscience summarizes the state of the art in high-throughput approaches (collectively known as 'OMICs') in neurology and neuroscience, and is of interest to both neurologists tracking the progress of these methods towards clinical applications, and neuroscientists curious about the most recent advances in this ever-changing field.

Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments.

In recent years, because of advances in karyological techniques, we have witnessed a remarkable renewal of interest in studies of mammalian chromosomes.

This book draws on fields as diverse as biochemistry, physiology, pharmacology, psychology, psychiatry, and ethology, to form a fascinating synthesis of information on the nature of fear and of panic and anxiety disorders.

"e;His groundbreaking work has changed the very ways we consider our health and examine disease.

The purpose of this workshop was to assess the value of DNA polymorphisms for the prediction, diagnosis or elucidation of aetiology for common metabolic diseases such as diabetes, hyperlipidaemia and atherosclerosis.

This book introduces readers to Next Generation Sequencing applications in medical genetics.

This book provides a unique overview on the most recent developments in initially diverse areas of behavioral genomic research that now start to intertwine to provide more detailed insights into the complex nature of behavior in health and disease.

The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function.

During the past two decades, our understanding of the molecular genetics of inherited eye diseases, their classification, and management has undergone a huge expansion as the field of human genetics has benefited from technological advances and increased interest by physicians and scientists in all fields.

This book is a collection of principles and current practices in omics research, applied to skeletal muscle physiology and disorders.

An ultra-concise, evidence-based guide to the initial patient encounterPoint of Care Medicine delivers the most patient-care information in the least amount of words possible.

In the fifty years since DNA was discovered, we have seen extraordinary advances.

Neurological illnesses pose one of the biggest hazards to the healthcare system today.

Much research has focused on the basic cellular and molecular biological aspects of stem cells.

Could Lincoln have lived?

How will increased understanding of the human genome affect our ability to diagnose and treat disease?

This book reviews the current state of ocular drug therapy and future therapeutic opportunities for a wide variety of conditions, including Age-related Macular Degeneration, Diabetic Retinopathy and Macular Edema, Glaucoma, and Inherited Retinal Diseases.