Medicinal chemistry

This volume highlights natural products, molecular methods for identifying, and current trends in designing non-natural natural products.

Animal Cell Biotechnology: Methods and Protocols, Fourth Edition constitutes a comprehensive manual of state-of-the-art techniques for setting up mammalian cell lines and media for development of biopharmaceuticals, and optimizing critical parameters for cell culture considering the whole cascade from the lab to the final production.

This collection explores detailed experimental protocols necessary for setting up a variety of in vitro cytochrome P450 (CYP) assays that are vital in selecting drug candidates in a drug discovery pipeline.

This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action.

This fully updated volume presents a wide range of methods for synthesis, surface modification, characterization and application of nano-sized materials (nanoparticles) in the life science and medical fields, with a focus on drug delivery and diagnostics.

This volume looks at applications of quantum mechanical (QM) methods in drug discovery.

This book aims to provide a guide to researchers on how to work with Transient Receptor Potential (TRP) channels, describing current methodologies and protocols, and highlighting the challenges ahead that will require the development of new technologies.

This detailed book focuses on analytical separations by chromatographic and electrophoretic techniques, providing some overview along with numerous practically-oriented applications of the most important analytical techniques in chiral separation sciences.

This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature's cyclic peptides and macrocycles.

This book presents key methodologies, tools and databases for biochemistry, microbiology and molecular biology in simple and straightforward language.

This book explores cutting-edge methods to work with the notoriously difficult, but highly prevalent, obligate intracellular pathogen, Chlamydia trachomatis.

This second edition book explores breakthrough technologies in the field of drug target identification and validation.

This volume details protocols on formulation, surface modification, characterization, and application of a variety of pharmaceutical nanocarriers such as micelles, nanoparticles, dendrimers, carbon dots, polymersomes, and others.

This detailed book explores techniques commonly used for research into drug repurposing, a well-known strategy to find alternative indications for drugs which have already undergone toxicology and pharma-kinetic studies but have failed later stages during the development, via computational methods.

This third edition volume expands on the previous editions with new topics that cover drug discovery through translational bioinformatics, informatics, clinical research informatics, as well as clinical informatics.

This comprehensive volume collects a repertoire of techniques for the adoption and exploitation of RNA interference (RNAi) as a fertile strategy to develop the bio-drugs of future in the vital field of cancer research.

Many physiologically important receptors and enzymes are regulated by their endogenous ligands and inhibitors.

Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one "e;how to"e; manual for basic scientists interested in initiating a drug discovery effort.

Infectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide.

Drug research has been greatly transformed by the "e;omics revolution"e; and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS).

With significant developments in the areas of chromatography and spectroscopy as well as the unique inherent chemical diversity of natural products, vital in drug research, natural products research has gained new momentum.

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body.

Over the past three decades there have been new developments in therapeutic drug design.

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs.

Microtubules are essential components of the cytoskeleton, and play critical roles in a variety of cell processes, including cell shaping, intracellular tracking, cell division, and cell migration.

There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences.

The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential.

The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate.

A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition.

Das Abweichungsmanagement ist eines von vielen Qualitätssystemen in pharmazeutischen Unternehmen.

Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery.

This book addresses the recent trends and clinical research being reported in last 5 to 10 years in the field of nasal drug delivery systems.

The book targets new advances in areas of treatment and drug delivery sciences for tuberculosis.

This detailed volume presents a series of protocols dealing with different aspects of inclusion body (IB) processing, from cloning procedures to purification of refolded product.

This book outlines the use of supramolecules as different pharmaceutical drugs.

This book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations.

The book Function-oriented bioengineered skin equivalents -  continuous development towards complete skin replication aims to provide potential readers with a comprehensive summary of the available information on various in vitro skin models, from historical background to different modeling approaches and their applications.

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In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability.

This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology.

This book casts new light on the field of oral drug absorption.

This book on "e;Renin-Angiotensin System in Cardiovascular Disease"e; includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects.

This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids.

This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells.

This book focuses on the different compounds (polyphenols, sterols, alkaloids terpenes) that arise from the secondary metabolism of plants and fungi and their importance for research and industry.

this book, the validation of bioanalytical methods is described.

This book targets new advances in areas of treatment and drug delivery sciences for Malaria.

Practical Pharmaceutics contains essential knowledge on the preparation, quality control, logistics, dispensing and use of medicines.