Medicinal chemistry

This volume begins with a short history of malaria and follows with a summary of its biology.

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application.

This book, by bringing together critical pharmaceutical studies and feminist technoscience studies, explores the way drugs produce sexed and/or gendered identities for those who take - or resist - them, and how feminist technoscience studies can contribute a theoretical lens with which to observe sex and gender in the pharmaceuticalization processes.

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology.

Originally published in French, this updated and expanded English translation offers a definitive treatment on clays and effects on human health including the long history of clays used as pharmaceutical and therapeutic agents, the origins of clays, their structural properties and modes of action.

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments.

This book explores technological innovation in family firms, seeking to reconstruct the links between the heterogeneous dimensions of family businesses and their innovative behaviour.

Focusing on the application of nanotechnology in pharmaceutical technology the editors seek to integrate the two in order to obtain innovative products and solutions in pharmacology.

The first contribution describes apolar and polar molecular fossils and, in particular biomarkers, along the lines usually followed in organic chemistry textbooks, and points to their bioprecursors when available.

This book reviews the principles of design and examples of successful implementation of proteinkinase inhibitors (PKI), and offers a comprehensive and authoritative overview of the history and latest developments in the field.

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants.

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies.

This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles.

This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds.

This volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.

This book provides a detailed summary of the therapeutic benefits of natural extracts from medicinal plants, mushrooms, algae, fungi and sponges and their role in the prevention and treatment of obesity and diabetes, offering readers a solid introduction to obesity and diabetes as well as current treatment models.

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies.

The editors have engaged leading scientists in the field to participate in the development of this book, which is envisioned as a "e;one of a kind"e; contribution to the field.

This third and final volume in the "e;Ion Transport in Tumor Biology"e; collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins.

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon.

This thesis discusses the use of asymmetric organic catalysis for the direct enantioselective synthesis of complex chiral molecules, and by addressing the many aspects of both vinylogy and atropisomerism, it appeals to researchers and scholars interested in both areas.

This book addresses the consequences of high agricultural pesticide use over the last few decades in the form of organophosphate poisoning.

The inflammasome is a protein complex composed of an intracellular sensor-typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC.

This book on classification in biomedical image applications presents original and valuable research work on advances in this field, which covers the taxonomy of both supervised and unsupervised models, standards, algorithms, applications and challenges.

This book presents the synthetic methodologies as well as the properties and potential usage of various ruthenium-containing materials.

This book addresses the most important aspects of how to plan and evaluate clinical trials with a composite primary endpoint to guarantee a clinically meaningful and valid interpretation of the results.

Based on a fundamental understanding of the interaction between bacteria and materials, this timely volume emphasizes the latest research in the antimicrobial interfacial design and provides an invaluable blueprint for improving antimicrobial performance on devices and products.

This volume offers the most comprehensive coverage on fetal programming.

The author has summarized a decade of teaching combinatorial chemistry into this timely brief.

The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds.

Proteins are exposed to various interfacial stresses during drug product development.

This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field.

This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities.

This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds.

Medicinal chemistry is both science and art.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology.

Medicinal chemistry is both science and art.

This brief traces the story of one of our most common medicines - aspirin.

This book presents the proceedings of the 39th annual Midwest Biopharmaceutical Statistics Workshop (MBSW), held in Muncie, Indiana on May 16-18, 2016.

The book HSP70 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP70 family - one of the most studied HSP - in human diseases and disorders.

This volume builds upon the successful book Lanthanide Luminescence published in the Springer Series on Fluorescence in 2011.

Although the Bioequivalence (BE) requirements in many global jurisdictions have much in common, differences in certain approaches and requirements such as definitions and terms, choice of comparator (reference) product, acceptance criteria, fasted and fed studies, single and multi-dose studies, biowaivers and products not intended for absorption into the systemic circulation (locally acting medicines and dosage forms), amongst others, provide food for thought that standardisation should be a high priority objective in order to result in a harmonized international process for the market approval of products using BE.

This book explains theoretical and technological aspects of amorphous drug formulations.

This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms.

The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting.

This volume discusses hazardous environmental micropollutants, their impacts on human health, and possible means to mitigate their associated risks.

Medicinal chemistry is both science and art.

The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye.

This is the first of three volumes in the "e;Ion Channels & Transporters in Tumor Biology"e; collection, which discusses the function of ion transport proteins in cellular and systemic homeostasis.