Medicinal chemistry

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook.

This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases.

This reference work provides comprehensive information about the bioactive molecules presented in our daily food and their effect on the physical and mental state of our body.

This book focuses on the envelope of Gram-positive bacteria including its composition, the latest discoveries in the mechanisms behind its assembly, and its role in pathogenesis.

This second edition of Clinical Use of Anti-Infective Agents provides a comprehensive overview of current approaches to using drugs to treat infections, including historical perspectives, definitions, and discussion of pharmacokinetics and pharmacodynamics and their uses.

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities.

This major reference work is a one-shot knowledge base on electroporation and the use of pulsed electric fields of high intensity and their use in biology, medicine, biotechnology, and food and environmental technologies.

Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases.

The book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR).

This fundamental book presents the most comprehensive summary of the current state in chemistry of cage metal complexes.

This comprehensive volume captures the latest scientific evidence, technological advances, treatments and impact of biotechnology in hyperbaric oxygen therapy.

This book comprehensively covers all aspects of distribution, taxonomy, life cycle, cultivation, application in traditional medicine, their secondary metabolites, and their biological properties, along with various parameters to yield improvement in selected species of Cordyceps.

Volume V of this manual provides an overview of the analytical investigation of numerous additional Chinese herbal drugs that are commonly used in Traditional Chinese Medicine (TCM).

This set of six volumes provides a systematic and standardized description of 23,033 chemical components isolated from 6,926 medicinal plants, collected from 5,535 books/articles published in Chinese and international journals.

This second book of the three-volume collection "e;Ion Transport in Tumor Biology"e; helps readers gain comprehensive knowledge of the pathophysiology of cancer.

Each year for the past three years, there have been about 50 new molecular medicines approved by the United States Food & Drug Administration (FDA), of which approximately 25% were new biopharmaceuticals.

This book presents three types of synthetically cooperative DNA recognizing assemblies, in order to advance the development of programmable DNA-binding pyrrole-imidazole polyamides (PIPs).

A suitable drug delivery system is an essential element in achieving efficient therapeutic responses of drug molecules.

This fundamental book presents the most comprehensive summary of the current state in chemistry of cage metal complexes.

This book covers several important aspects of pharmaceutical research and innovations.

Biomaterials for Clinical Applications is organized according to the World Health Organization's report of the top 11 causes of death worldwide, and lays out opportunities for both biomaterials scientists and physicians to tackle each of these leading contributors to mortality.

The inflammasome is a protein complex composed of an intracellular sensor-typically a Nod-like receptor (NLR), the precursor procaspase-1, and the adaptor ASC.

This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles.

This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way.

This book addresses a range of synthesis and characterization techniques that are critical for tailoring and broadening the various aspects of polymer gels, as well as the numerous advantages that polymer gel-based materials offer.

This reference work provides comprehensive information about the bioactive molecules presented in our daily food and their effect on the physical and mental state of our body.

This volume contains a collection of innovative techniques for studying targeted protein degradation.

This book describes the state of the art in the field of bioanalytical nano- and microsystems with optical functionality.

This volume focuses on the biomedical aspects of inorganic polyphosphates, a family of unique bio-inorganic polymers.

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY).

Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes.

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles.

The formation of disulphide bonds is probably the most influential modification of proteins.

Medicinal chemistry is both science and art.

Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment.

This thesis offers readers a comprehensive introduction to amyloid proteins and the computational methods used with them.

This book covers sugar, salt and milk fat from a chemical perspective, and presents an overview of the role of these ingredients in our food, focusing on their flavors, satiety-inducing properties, nutritional impact, and health effects.

This book provides a comprehensive overview of the multifaceted field of protease in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology.

With improved control of most environmental causes of disease, genetic illness has assumed a primary importance in the causation of handicap and mortality in all age groups.

The period between 1950 and 1980 were the golden unique insights into how pathological processes affect years of transmission electron microscopy and produced cell organization.

This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases.

This detailed book focuses on analytical separations by chromatographic and electrophoretic techniques, providing some overview along with numerous practically-oriented applications of the most important analytical techniques in chiral separation sciences.

This book, with its 16 chapters, documents the present state of knowledge of the adenosine A receptor.

The legislative requirement for cannabis to undergo laboratory testing has followed legalization of medical and recreational use in every U.

The papers collected in this volume represent the formal proceedings of the Third European Symposium on Calcified Tissues which was held in Davos, Switzerland from 11th to 16th April 1965 under the sponsorship of the Laboratorium fur experi- mentelle Chirurgie, Schweizerisches Forschungsinstitut Davos.

Clinical Trial Registries: A Practical Guide for Sponsors and Researchers of Medicinal Products is a necessary addition to the library of all researchers who plan to publish their results in top-tier, peer-reviewed journals.

This book addresses chemical and biological aspects related to sesquiterpene lactones (STLs).

This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation.