The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene.
Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and pathology of elastin at the molecular level.
This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications.
Experts in their respective fields present papers concerned with the range of human diseases caused by defective or abnormal functioning of cell adhesion molecules.
Contains the presentations and discussions that took place during a symposium at the CIBA Foundation on October 1-3, 1990 on the subject of catalytic antibodies.
Composed of contributions from experts in the chemical and biological sciences, it explores host-guest molecular interactions leading to the formation of molecular assemblies containing two or more species.
Useful throughout history for their medical as well as other benefits, plant-derived compounds have gained particular importance recently, due to environmental factors.
The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results.
The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry.
An Introduction to Aqueous Electrolyte Solutions is a comprehensive coverage of the subject including the development of key concepts and theory that focus on the physical rather than the mathematical aspects.
This volume concentrates on catalysis in biochemical environments, giving new perspectives to previous research, current developments and future directions.
This thoroughly updated open learning text provides an introduction to electroanalytical chemistry, one of today's fastest growing and most exciting frontiers of analytical science.
Covering the huge developments in sensor technology and electronic sensing devices that have occurred in the last 10 years, this book uses an open learning format to encourage reader understanding of the subject.
There is an increasing need for analysts to understand and be able to quantify the performance of analytical instruments, in particular with respect to the following: * specifying equipment for purchase * estimating uncertainties in intrumental measurements * quantifying and demonstrating performance quality This text links together an understanding of performance characteristics with an appreciation of the limitations imposed by instrument design, leading to the interplay of the validation and qualification processes within quality assurance systems.
The latest edition of the authoritative reference to HPLC High-performance liquid chromatography (HPLC) is today the leading technique for chemical analysis and related applications, with an ability to separate, analyze, and/or purify virtually any sample.
The Compendium of Organic Synthetic Methods series facilitates the working chemist's search for the most useful functional group transformations in organic chemistry.
Written by one of the pioneers of 2D X-Ray Diffraction, this useful guide covers the fundamentals, experimental methods and applications of two-dimensional x-ray diffraction, including geometry convention, x-ray source and optics, two-dimensional detectors, diffraction data interpretation, and configurations for various applications, such as phase identification, texture, stress, microstructure analysis, crystallinity, thin film analysis and combinatorial screening.
A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR).
Pertaining to homeland security, this title is a comprehensive guide to radiation protection caused by accidents or terrorism Provides essential strategies and guidance for protecting ports and examines the latest nuclear detection devices that can be deployed Explains the procedures in FEMA's "e;National Incident Management System"e; Gives specific details for first responders and emergency workers on how to prepare for and handle radiological incidents
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.
The New Edition of the Well-Regarded Handbook on Gas Chromatography Since the publication of the highly successful first edition of Basic Gas Chromatography, the practice of chromatography has undergone several notable developments.
Brings together, analyzes, and contextualizes the latest findings and practical applications Polyphosphazenes, an emerging class of polymers, include macromolecules, which have been proven to be biocompatible, biodegradable, and bioactive.
The complex roles of glutathione and sulfur amino acids in human health Glutathione ( -L-glutamyl-L-cysteinylglycine, GSH) is a major antioxidant acting as a free radical scavenger that protects the cell from reactive oxygen species (ROS).
Covers powerful new tools for drug development Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality.
The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants.
Design and Construction of Coordination Polymers Edited by Mao-Chun Hong Ling Chen A Unique Resource on coordination Polymers Coordination polymers are a growing, interdisciplinary field with numerous potential applications in chemistry and materials.
Wiley Series on Electrocatalysis and Electrochemistry Fuel Cell Catalysis A Surface Science Approach A Core reference on fuel cell catalysis Fuel cells represent an important alternative energy source and a very active area of research.
A lively account of fluoridation and its discontents Since its first implementation in Grand Rapids, Michigan, in 1945, public drinking water fluoridation and its attendant conflicts, controversies, and conspiracy theories serve as an object lesson in American science, public health, and policymaking.
A unique, integrative look at information-based medicine The convergence of medical science, biology, pharmacology, biomedical engineering, healthcare, and information technology is revolutionizing medical and scientific practice, and has broader social implications still being understood.
Important safety aspects of compatibility for therapeutic products and their manufacturing systems, delivery devices, and containers Compatibility of Pharmaceutical Products and Contact Materials helps pharmaceutical, toxicology, analytical, and regulatory affairs professionals assess the safety of leachable and extractable chemicals associated with drug product packaging, manufacturing systems, and devices.
Destined to become every regulatory director's essential desktop companion Professionals working to submit major documents to the Food and Drug Administration (FDA) are guaranteed to encounter numerous unexpected and daunting hurdles.
