Immunology

In light of the critical contributions of macrophages and dendritic cells to diverse inflammatory diseases and to immunity and host defense, state-of-the-art approaches to the investigation of their behavior are essential.

From the early days when RNA interference was a strange artifact in worms to the 2006 Noble Prize received by Fire and Mello and the current clinical trials, the field of RNA interference has grown at a breakneck pace.

Monoclonal Antibodies: Methods and Protocols examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting with opening chapters focusing on the gold standard method for generating mouse monoclonal antibodies through hybridoma technology, future methods for engineering recombinant and humanized antibodies, methods for engineering soluble Fc fusion protein, and the use of antibodies and flow cytometry in the quantification of cell signaling proteins.

Antibodies tagged with fuorescent markers have been used in histochemistry for over 50 years.

The rapidly growing field of antibody research is the result of many advancing technologies allowing current developments to take advantage of molecular engineering to create tailor-made antibodies.

A continuously evolving technique, immunotherapy for the treatment of cancers now incorporates the use of immune cells infused during bone marrow transplants as well as approaches like cell and gene therapy, while stem cell-based therapies, tissue engineering, and targeting have also contributed to the latest successes in pre-clinical immunotherapy studies.

A compendium of optimized methods to measure type I interferon efficacy as an antiproliferative or an antiviral agent.

In the early 1990s, almost 200 yr after Edward Jenner demonstrated the effectiveness of the smallpox vaccine, a new paradigm for vaccination emerged.

A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells.

Cell Cycle Control and Dysregulation Protocols focuses on emerging methodologies for studying the cell cycle, kinases, and kinase inhibitors.

Cytokines in Human Health: Immunotoxicology, Pathology, and Therapeutic Applications explores the role of cytokines in immunotoxicology and human health using a variety of complex methods, from basic research to highly applied therapeutic applications.

Over the last half century, a dramatic increase in allergic diseases has been observed throughout industrialized nations, which has resulted in significant worldwide socio-economic challenges.

Immunoelectron microscopy is a key technique that bridges the information gap between biochemistry, molecular biology, and ultrastructural studies placing macromolecular functions within a cellular context.

After decades of research in clinical transplantation, new techniques have been developed that permit a further understanding of the immune mechanisms underlying immune recognition of allografts and a more accurate and thorough evaluation of compatibility between donors and recipients.

Spanning from discoveries in fundamental immunology to industrial and commercial concerns, the study of vaccine adjuvants has developed into an exciting area of work with great, vital potential in innovating techniques in which adjuvants may steer the immune system towards the responses required by unmet vaccination needs.

A crisis is developing in the treatment of infectious diseases, with microorganisms frequently showing resistance to currently prescribed antibiotics.

Despite major advances in HIV treatment, many areas require more study, in order to create efficacious, potent antiretrovirals that can suppress viral load completely and durably without toxic side effects, to define unknown drug targets and fine-tune known targets, and to better understand the interplay between viral and host factors.

Given the vital importance of immune system research, the gathering of clear, consistent, and informative protocols involving the study of dendritic cells is paramount.

Given the versatile utility of the determinination of epitopes, beneficial to a wide variety of scientists from immunologists to structural biologists to biotechnologists, the need for a thorough, state-of-the-art collection of experimental protocols is clear.

For researchers today, the avidin-biotin interaction is among the most widely exploited among biomedical scientists.

For over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied, garnering much attention due to their broad therapeutic efficacy.

Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity.

Bacterial infections affect world health today as a leading cause of morbidity and mortality.

Unlike detecting constitutively expressed targets, immunohistochemical detection of labile, low abundance, and short-lived signal transduction molecules can be a very difficult task.

Immunological Tolerance: Methods and Protocols is a comprehensive guide to the techniques currently used for culturing and characterising the cell types responsible for imposing self-tolerance and the experimental models employed to study their function both in vitro and in vivo.

The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles.

Human Retroviruses: Methods and Protocols collects key experimental protocols that have provided the basis of the major discoveries of the field.

Over the past several years, a high diversity of regulatory cells and suppressive molecules has taken centre stage in the field of immunoregulation.

In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories.

The development of the hybridoma technology created the possibility to obtain unlimited amounts of monoclonal antibodies (mAb) with high specificity and affinity for any target and to introduce mAbs in a wide range of applications; however, the bulky size of mAbs, costly production, and cumbersome engineering hampered regularly their streamlined development in some applications.

The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells.

A memoir of the authors twenty-five-year, self-designed experiment with a nonpharmaceutical approach to multiple sclerosis and of the indomitable mother who taught her to meet trouble with active resistance.

Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting chapters on timely topics, including Epigenetically Programmed Resistance to Chemotherapy and Promotion of Immune Evasion in Cancer, A Role for the Epigenome in Cancer Cell Drug Tolerance, Histone Methylation and X Chromosomal Genes in Metastasis of Breast Cancer, Targeting Epigenetic Regulation Using Small Molecule Inhibitors, Histone Deacetylase Inhibitors as Sanguine Epigenetic Therapeutics against Pugnacious Lung Cancer, From ecology to oncology: To understand cancer stem cell dormancy, ask a Brine shrimp (Artemia), and more.

The bestselling author of The Ripple Effect shows you easy ways to boost your energy, fight inflammation and optimize your healthcell by cellYour body is constantly rebuilding, depending on what you do, eat and even think.

From the paradigm-shifting author of Anti-Diet comes a deep dive into the underbelly of modern wellness culture and how it stands in the way of true well-being.

"e;Research is to see what everybody else has seen, and to think what nobody else has thought.

Imaging Inflammation provides updates on cutting-edge imaging methods being applied to problems in inflammation research.

This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale.

Inmunología.

This book examines the issue of immunity with the signaling pathways it is associated with, which has come to the fore again with the COVID-19 pandemic.

Translational Autoimmunity: Advances in Autoimmune Rheumatic Diseases, Volume Six addresses autoimmune diseases classified under the category of rheumatic diseases.

This volume provides an understanding of how an immunoassay works, detailing the strengths, weaknesses, pitfalls.

This fully revised and expanded second edition provides a comprehensive and up-to-date overview of nasal physiology and pathophysiology.

Eine schwere postvirale Multi-Infektion setzt sämtliche Lebenspläne einer jungen Frau völlig außer Kraft.

The Comprehensive Guide to Hepatitis Advances provides the most up-to-date information on all types of hepatitis in one resource.

This book covers a wide range of diverse immunoinformatics research topics, involving tools and databases of potential epitope prediction, HLA gene analysis, MHC characterizing, in silico vaccine design, mathematical modeling of host-pathogen interactions, and network analysis of immune system data.

Examines how ozone therapy disables viruses, fights inflammation and bacteria, and enhances the immune system*; Explores the science and history of ozone therapy as well as its success in the treatment of viruses and infections, such as Covid-19 and Lyme disease*; Presents articles from leading ozone therapy doctors and researchers, including Robert Rowen, M.

A full-color guide to the healing uses of the natural substance Shilajit*; Explores how to use Shilajit for a strong immune system, enhanced cognitive performance, protection from toxic stress, healing inflammation, and anti-aging benefits*; Presents a scientific analysis of the many cell-protecting, antioxidant, and vitalizing compounds found in Shilajit*; Looks at its different forms and dosages and how to combine it with other health supplements to enhance its extraordinary benefitsA complete guide and fact-based portrait of Shilajit as a substance with long-standing tradition in Ayurvedic and Chinese medicine, along with Russian folk medicine.

This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018).