During the course of editing 'Supportive Care in Cancer Therapy' (Martin us Nijhoff Publishers, 1983), it become apparent that several topics would have to await a second volume.
Interferon alpha-2 is a genetically engineered, highly purified pharmaceutical agent that has undergone extensive phase I and phase II clinical study in more than 1000 patients.
The observation in the 1950s that nitrogen mustard and other toxic chemicals could induce antitumor responses in patients with refractory lymphoma initiated a massive search for active chemotherapeutic agents.
Biochemical Modulation at the present time defines an area of study in which the intracellular metabolism of a given anti- cancer agent is modulated (usually by a noncytotoxic agent or a cytotoxic agent at sufficiently low dosage to make it non- cytotoxic) in order to either increase the effectiveness of the particular agent against tumor cells or decrease its cytotox- icity against normal cells.
Although soft tissue sarcomas are rare tumors, representing only 1 % of all malignant tumors in adults, they remain a challenge to all disciplines in medical treatment and research.
The methodology of drug development has been the subject of extensive dis- cussion by a relatively small group of individuals in industry and government who have been intimately concerned with the identification and study of new anticancer drugs.
The control of breast cancer, a leading cause of cancer death in women, will depend ultimately on our understanding of the disease--its origin, and progression which in turn will permit the effective management of its treatment, its detection, and perhaps even its prevention.
The theme of the current workshop was identified several years ago and was considered by the working group of the National Large Bowel Cancer Project to be an appropriate workshop topic.
The success rate for treatment of primary neoplasms has improved sig- nificantly due to improved surgical, radiotherapy, and chemotherapy methods, and by supportive patient care.
Since the early times of the Greek philosophers Leucippus and Democritus, and later of the Roman philosopher Lucretius, a simple, fundamental idea emerged that brought the life sciences into the realm of the physical sciences.
One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment.
Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible.
These proceedings emanate from the Second Prouts Neck Conference on prostate cancer held on October 17-19, 1986, the theme of which was treat- ment, with focus on current issues and future research that is needed to answer critical questions related to optimal management of the various stages of prostate cancer.
This book presents in a comprehensive way cur- the clinical care of the patient with head and neck rent advances in the management of neoplasia cancer involvement and/or its complications.
The chapters in this book are those presented at the Second International Symposium on Fundamental Problems in Breast Cancer held at Banff, Alberta, April 26-29, 1986.
Cytological screening for the identification of intraepithelial neoplasia of the cervix as a precursor lesion for cervical cancer has been well established as an effective means for decreasing the incidence of invasive carcinoma.
Volume 9 of Chemical Mutagens consists mainly of chapters discussing the development and validation of short-term assays to detect the mutagenic effects of environmental chemicals.
This publication is based on a Symposium that has been held in Clearwater, Florida on February 19-21, 1986, on antibodies, their structure, synthesis, function, and clinical applicability in disease.
The last volume dealing with lung cancer in this series in Cancer Treatment and Research was published in 1986 and entitled Lung Cancer: Basic and Clinical Aspects.
The theme of this 14th International Symposium on Blood Transfusion is closely related to the work and scientific contributions of the Dutch cryobiology pioneer Dr.
It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease.
Causes and Control of Colorectal Cancer: A Model for Cancer Prevention is a ground- breaking monograph which takes a global, multidisciplinary approach to the causes, carcinogenesis and control of colorectal cancer.
