Type IV secretion systems (T4SSs) are highly versatile membrane-associated transporter machines used by Gram-negative and Gram-positive bacteria to deliver substrate molecules to a large variety of target cells.
Adopting a truly global perspective and a practical approach to diabetes-including pathophysiology, genetics, regional peculiarities, management, prevention and best practices-this book is an excellent resource for clinicians and policy-makers working with patients in more austere settings.
This book gathers a collection of cases with challenging diagnoses, in which nuclear medicine examinations have been particularly helpful in terms of the final diagnosis or follow-up.
Originally published in 2010, this book has since become one of the seminal works in the rapidly evolving field of body piercings, tattoos, and permanent make-up.
This book reviews the principles and applications of radiotherapy in the management of pediatric brain tumors to allow the reader to gain a full appreciation of the major aspects involved in caring for these patients.
Infections caused by fungi have recently attracted the attention of both clinicians and basic researchers given the heavy burden they represent for any health system.
This up-to-date, hands-on manual offers clear guidance on contouring and treatment planning for both standard and advanced radiation therapy in patients with gastrointestinal cancers and simultaneously draws together the available relevant clinical data for each type of cancer with a view to driving treatment recommendations.
The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop.
Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies.
Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment.
Integrating care across disciplines and organisations around the needs of the person with diabetes has been proposed as an approach that could improve care while reducing cost- but has it and can it?
This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer.
Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys.
This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists.
The purpose of this book is to define and demonstrate how a multidisciplinary team can be organized, integrated, and utilized in the care of sarcoma patients.
This book highlights the role of the Translationally Controlled Tumor Protein (TCTP) in cell signaling, cell fate and the resulting connection to disease development.
This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach.
This book, now in an extensively revised and updated second edition, provides a comprehensive overview of both machine learning and deep learning and their role in oncology, medical physics, and radiology.
This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary.
The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1?
This book deals with the advantages of using artificial intelligence (AI) in the fight against the COVID-19 and against future pandemics that could threat humanity and our environment.
This volume comprehensively covers the multiplicity and diversity of mechanisms underlying patient resistance to currently approved anti-cancer drugs, including tyrosine kinase inhibitors and monoclonal antibodies, blockers of growth factor receptors and their downstream pathways, which play essential functions in cancer progression.
This book focuses on malignant melanoma, discussing the current state of scientific knowledge and providing insights into the underlying basic mechanisms, the molecular changes, genetics and genomics.
This book is a compilation of some of the most remarkable contributions made by scientists currently working in Latin America to the understanding of virus biology, the pathogenesis of virus-related diseases, virus epidemiology, vaccine trials and antivirals development.
This book provides a comprehensive overview of the scientific, medical, regulatory, and economic considerations associated with the discovery, development, and delivery of novel therapeutics for children with cancer.
The book provides, in a comprehensive yet concise way, essential information to improve the knowledge and skills of all healthcare providers involved in the treatment of patients with breast cancer.
This book summarizes the results achieved so far by application of various biological systems (including genomics, transcriptomics, proteomics, and metabolomics) involved in the pathomechanisms and early diagnosis of periparturient diseases as specific biomarkers of disease in cattle.
This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases.
This book fills the need for a simplified text covering western blotting protocols aimed not just at high school and college students, but the researcher with little to no experience in these techniques.
In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status.
This volume focuses on IgG4-related disease (IgG4-RD), a novel clinical entity involving multiple organs and of unknown origin, associated with the abundant infiltration of IgG4-positive cells.
This book provides a clear and comprehensive guide to the clinical prescription of lithium that draws upon evidence-based knowledge of its mechanisms of action.
This book is designed to present a comprehensive and state-of the-art approach to the management of adrenal neoplasms that provides a resource to the broad group of providers that will encounter such a patient.
This book describes the pathways of dissemination of primary liver, biliary, and pancreatic neoplasms and proposes a practical and clinically driven approach to their imaging.
