This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens.
This book summarizes microRNA (miRNA) biology in a variety of pathological processes, emphasizing the significant potential applications of miRNA in diagnostics and prognostics, as well as novel drug targets.
This book concisely but thoroughly summarizes advances in understanding of the spectrum of orbital inflammatory disorders that have resulted from recent basic and clinical research and explains their significance for clinical practice.
Recent advances in the field of recombinant antibodies have permitted the manipulation of genes encoding specific antibodies, thus allowing their ectopic expression in a wide variety of non-lymphoid cells.
This book gives a very timely account of recent - partly unpublished - research on the development of gram-positive bacteria as vaccine delivery vehicles for mucosal immunization.
Flow cytometric analysis of molecular, biochemical, genetic and developmental parameters using cellular fluorescence techniques as well as fluorescence-activated (FACS) or magnetic (MACS) cell sorting technologies provide unique options for molecular and cellular biology.
The chicken is a useful model for research into the basic features of immunology because its immune system functions in a way similar to that of human beings and because the chicken embryo is easily accessed experimentally.
Tuberculosis has plagued mankind since prehistoric times and is still an important source of morbidity and mortality, with particularly devastating effects in developing and tropical countries.
The containment of cell growth is at the core of the homeostatic regulation of metazoans, and considerable progress has been made in the understanding of how this is achieved.
Most lymphocytes recirculate throughout the body, migrating from blood through organized lymphoid tissues such as lymph nodes (LN) and Peyer's patches (PP), then to lymph and back to blood (GOWANS and KNIGHT 1964).
More than 10 years ago, the discovery of cyclin-dependent ki- nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control.
The mouse was first used in immunological research by Paul Ehrlich in 1891 in an extraordinary series of experiments on the maternal transfer of antitoxic immunity.
Discrimination of self from nonself is the major function of the immune system and understanding the mechanism(s) involved a main employer of immunologists.
Currently, the cellular and molecular mechanisms governing the development and regulation of the vasculature are studied in- tensely and the field is rapidly progressing.
Mucosal immunity encompasses a broad field of research that includes areas of epithelial cell and molecular biology, molecular and cellular immunology, microbiology, virology, and vaccinology.
The essence of combinatorial chemistry or techniques involving "e;molecular diversity"e; is to generate enormous populations of molecules and to exploit appropriate screening techniques to isolate active components contained in these libraries.
Novel molecular motifs named Immunoreceptor Tyrosine-based Inhibition Motifs (ITIMs) have recently been recognized in the intracytoplasmic domains of a still-increasing number of receptors which control cell activation and proliferation.
