Diseases and disorders

The worldwide impact of infection with human immunodeficiency virus type 1 (HIV- is reflected in the cumulative number ofHIV- 1 infections, which is now predicted to exceed 40 million by the year 2000---equivalent to the n- ber of humans who perished in World War II.

This volume summarizes current cutting-edge methods related to carbohydrate-based vaccines, from the identification of a suitable carbohydrate antigen via the preparation of glycoconjugate vaccines to the characterization of vaccine candidates for their use in pre-clinical and clinical studies.

This expert volume provides insights into the technological fundamentals together with a comprehensive overview of the potentialities of peptide microarray technology in basic research and clinical assays.

Primer on Radiation Oncology Physics: Video Tutorials with Textbook and Problems, now in its second edition, provides over 60 tutorial videos (each 15-20 minutes in length) with a companion text and is the most complete and effective introduction to medical physics available.

The enormous advances in molecular biology that have been witnessed in .

Dendritic Cell Protocols provides chapter and verse for many useful practical approaches to the art of studying dendritic cells.

This book discusses the scope and limitations of complex reconstructive surgery that few plastic surgeons master, and that the public rarely encounters, portraying both the technical challenges of advanced reconstructive microsurgery and the human connection between physician and patient as only a master surgeon can convey.

Interleukins are a family of proteins that regulate the maturation, diff- entiation, or activation of cells involved in immunity and inflammation, and belong to a broader family termed cytokines.

Cytogenetic studies of malignancy have become an essential tool in the clinical management of cancer patients.

This book offers a comprehensive and multi-faceted examination of gastrointestinal inflammations, discussing factors that impact gut health.

The enormous advances in molecular biology that have been witnessed in .

This volume is a collection ofresearch methods, techniques, and approaches to investigate the molecularbiology of West Nile Virus (WNV).

Legionnaires' disease is a severe form of pneumonia that can occur in epidemics of several hundred cases.

According to the most recent clinical oncology data, one out of seven newly diagnosed malignancies worldwide result from infection and chronic inflammation in conjunction with cancer.

Public Health Microbiology: Methods and Protocols is focused on microorganisms that can present a hazard to human health in the course of everyday life.

A cutting-edge collection of readily reproducible techniques for the isolation, culture, and study of activation and signaling in human mast cells.

Complement Systems: Methods and Protocols is composed of 32 individual chapters that describe a variety of protocols to purify and analyze the activity of the individual complement components or pathways.

Thisvolume covers multidisciplinary approaches on various aspects of ChikungunyaVirus (CHIKV) research that was brought together from leading laboratoriesacross the globe.

The culture of cancer cells is routinely practiced in many academic research centers, biotechnology companies, and hospital laboratories.

This book contains critical background information, and recent advances made in essentially all areas of islet research.

In addition to their invaluable role in the fight against infection, Toll-Like Receptors (TLRs) in an under- or over-active state can lead to the pathogenesis of disease, making these receptors a key focal point for many research laboratories.

Virus-Host Interactions: Methods and Protocols covers various aspects of virological research, such as biochemical approaches, including molecular interactions and regulatory mechanisms on the protein as well as the RNA level with a strong focus on the manifold possibilities to study protein-protein interactions, as well as cell biological and immunological methodologies.

This volume is essential for geneticists, molecular biologists, biochemists, and medical doctors interested in the use of mouse models in cancer research.

There have been very few developments that markedly affect the need to greatly revise the text from the last version of this book.

This comprehensive guide serves as both an educational resource and a practical manual for surgeons performing gastric resections as well as clinicians involved in the care of gastric cancer patients.

In Basophils and Mast Cells: Methods and Protocols, experts in this challenging field explore techniques to research these cells from the most practical point of view.

Diabetes mellitus is the collective name for a group of diseases associated with hyperglycemia (high levels of blood glucose) caused by defects in insulin p- duction, insulin action, or both.

Given the versatile utility of the determinination of epitopes, beneficial to a wide variety of scientists from immunologists to structural biologists to biotechnologists, the need for a thorough, state-of-the-art collection of experimental protocols is clear.

This second volume expands upon the previous edition with new research and objectives in immunoregulation and immune tolerance.

Focused on the discovery of precise molecular targets for the development of the cancer preventive agents, Cancer Prevention: Dietary Factors and Pharmacology provides researchers and non-researchers with practical methodologies for developing and validating small molecule and phytochemical-derived drug discovery and mechanisms by which these compounds can modulate distinct target proteins involved in oncogenic signaling.

This book intends to introduce the basic concepts of B cell activation and its latest advances in biological research and disease treatment applications, including the structure and classification of B cell receptors, the process and mechanism of antibody-mediated B cell activation, and tumour immunity and monoclonal antibody therapies.

Enzyme-linked immunospot assay (ELISPOT) has been known for some time as a unique state-of-the-art technique for studying the cytokine-secreting activity of immune system cells, and it appears to be one of the fast growing applications in biomedical research, becoming an indispensable tool in vaccine development, HIV research, transplantation studies, and cancer and allergy research.

In Apoptosis and Cancer: Methods and Protocols, Second Edition, expert researches in the field detail the performance of molecular and cellular biology techniques for studying and detecting the activation of the apoptotic pathway.

Gene therapy has expanded rapidly over the last decade.

Ovarian cancer is the most lethal malignancy of the female reproductive system and is also the fifth leading cause of cancer death in women.

This book is a collection of protocols, to provide novel techniques for the study of the biology of T lymphocytes.

Cancer is a devastating disease that affects millions of people in the world.

This book discusses the scope and limitations of complex reconstructive surgery that few plastic surgeons master, and that the public rarely encounters, portraying both the technical challenges of advanced reconstructive microsurgery and the human connection between physician and patient as only a master surgeon can convey.

This collection seeks to elucidate the practical methods necessary for successful adjuvant development, with a particular focus on the synthesis, formulation, manufacturing, and characterization aspects involved.

Behavioral health conditions, which include mental health and substance use disorders, affect approximately 20 percent of Americans.

Since its introduction almost 20 years ago, phage display technology has revolutionized approaches to the analysis of biomedical problems, quickly impacting the fields of  immunology, cell biology, biotechnology, pharmacology, and drug discovery.

In 2003, the word "e;coronavirus"e; spread across the globe, somewhat further than the virus that sparked the panic.

Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents.

With the significant medical role that human cytomegalovirus plays in human disease (from acute disease following primary infection, to chronic disease due to life-long viral persistence), the need to better understand human cytomegalovirus biology and pathogenesis is needed.