Pharmacology

Conceptually unsavoury, airway mucus is vital to homeostasis in the respiratory tract.

Since the fortuitous discovery of its anticonvulsant activIty in 1962, valproate has established itself worldwide as a major antiepileptic drug against several types of epileptic seizures.

The tetracyclines have an illustrious history as therapeutic agents which dates back over half a century.

Stroke is a leading cause of death in developed countries.

There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research.

Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics could be useful in the treatment of diseases of the central nervous system.

Several new developments in the field of neuroimmunology with focus on the brain-to-immune system communication have been the incentive for this PIR volume.

Many advances have been made in the field of thermoregulation in the past few years.

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In November 1998 many of the key leaders of new drug discovery for inflammatory diseases gathered at Hershey, Pennsylvania for the 9th International Conference of the Inflammation Research Association.

Combinatorial chemistry in conjunction with High Throughput Screening (HTS) is revolutionizing the drug discovery process.

Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade.

Cytokines have become established as key mediators of the signs and symptoms of inflammatory diseases such as arthritis, dermatitis, asthma and multiple sclerosis.

The introduction of chlorpromazine in 1953, and haloperidol in 1958, into clinical practice dramatically altered the therapy of schizophrenic patients.

Heat shock proteins (HSP) have received ample interest by immunologists over recent years.

Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago.

Mit Hilfe der Bioinformatik können ermittelte DNA-, RNA- oder Aminosäuresequenzen hinsichtlich Struktur und Funktion schnell eingeschätzt werden; das spart Kosten und Zeit bei weiterführenden Experimenten im Labor.

This second volume of PDR SPECIAL TOPICS contains five review articles dealing with fungal diseases in humans as well as therapeutic approaches.

This drug is a landmark discovery, which consequently has become the definitive therapy for the treatment of erectile dysfunction (ED).

Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world.

In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced.

Chronic viral hepatitis has emerged as one of the most common causes of disease and death worldwide.

The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction.

COX-2 inhibitors are important drugs with analgesic and anti-inflammatory effects.

HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times.

During the past decade research into the pharmacology of cognition, particularly regarding learning and memory, has supported the concept that many potential neural targets exist for the development of cognitive-enhancing drugs.

How are cancer and inflammation interrelated mechanistically and clinically?

The drugs named calcium channel blockers (CCBs) were initially termed cal- cium antagonists (see Chapter 1).

Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids.

Alzheimer disease (AD) has become the most common form of dementia in industrialized countries and represents an increasing burden at the economic, social and medical level.

With the number of natural carotenoid structures reported rising above 700, there is a clear need for a single reference work containing data on all these compounds.

Einer kurzen Einleitung in das Werk Felix Hoffmanns, des 1946 verstorbenen Erfinders von Aspirin®, folgen vier separate Kapitel über die Wirkungsmechanismen der Acetylsalicylsäure, einschließlich ihrer Phamakokinetik.

Many factors may influence the release of neurotransmitters from airway nerves [1].