Pharmacology

Pharmacology in Drug Discovery and Development: Understanding Drug Response, Third Edition is an introductory resource that illustrates how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action.

An examination of the efficacy and safety of psychiatric medications in light of how little is understood about how they workIt is estimated that forty-five to fifty percent of all Americans will suffer a mental disorder at some time during their lives.

This comprehensive anatomy and histology book is the first guide specific to the pig since 1982.

The idea of using beta-blockers as a treatment for ventricular fibrillation occurred to James Black over 60 years ago.

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer.

Part of Springer's "e;The Receptors,"e; series, this text is the first ever overview on the research of 5-HT2c receptors.

Bladder cancer is a common cancer of the urinary tract.

Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate.

Endocrine disruption represents one of the most controversial environmental issues of our time.

A majority of the Fortune 500 Companies implement some practice of workplace drug testing in their company policies.

Ischemic brain damage represents a major source of morbidity and mortality in westernized society and poses a significant financial burden on the health care system.

Defined as, "e;The science about the development of an embryo from the fertilization of the ovum to the fetus stage,"e; embryology has been a mainstay at universities throughout the world for many years.

Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980's with its identification as an effector of phorbol esters, natural products with tumor promoting activity.

Much work over the last two decades has firmly established that loss of cell cycle checkpoint regulation, and resultant unabated cellular proliferation, is an inherent characteristic of cancer.

This indispensable book provides therapists and counselors with crucial knowledge about psychotropic medications: when and how to make medication referrals, how to answer patients' questions and help them handle problems that arise, and how to combine medication and psychotherapy effectively.

Many Healthcare workers must deal on a daily basis with the transportation, preparation, storage, clean up, and disposal of cytotoxic drugs, which are used in chemotherapy because of their harmful effect on cancer cells.

Cancers of the central nervous system are among the most lethal of human neoplasms.

Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978.

Metal Carcinogenesis Testing explains fundamental principles of metal carcinogenesis as they are currently understood, and provides detailed practical descriptions of rapid and inexpensive in vitro assay methodology presently in use for the detection of potentially carci- nogenic metals and their compounds.

Handbook of Drug-Nutrient Interactions, Second Edition is an essential new work that provides a scientific look behind many drug-nutrient interactions, examines their relevance, offers recommendations, and suggests research questions to be explored.

Functional selectivity refers to the ability of different ligands acting at one receptor subtype to activate multiple signaling pathways in unique combinations; that is, one drug can be an agonist at pathway A and an antagonist or partial agonist at pathway B, and another drug can have the reverse profile.

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders.

Nanomedicine is clinical medicine with the application of nanobiotechnology, which is currently being used to research the pathomechanism of disease, refine molecular diagnostics, and aid in the discovery, development and delivery of drugs.

The main objective of this book is to provide an up-to-date survey of the rapidly advancing eld of cancer therapy.

Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients.

The striatum is the principal input structure of the basal ganglia.

Telomerase, an enzyme that maintains telomeres and endows eukaryotic cells with immortality, was first discovered in tetrahymena in 1985.

Since the creation of the American Board of Clinical Lipidology, many clinicians have wanted an up-to-date, comprehensive reference on lipidology.

Biopharmaceutical Drug Design and Development, Second Edition, furthers the widely successful first edition, published in 1999.

Introduction to Systems Biology is an introductory text for undergraduate and graduate students who are interested in comprehensive biological systems.

As research has progressed, the cannabinoid CB 1 and CB 2 receptors have expanded significantly in importance within the neuroscience mainstream.

In Foodborne Diseases, leading authorities present a broad overview of the microbial pathogens and toxins associated with foodborne illness while discussing pathogenicity, clinical epidemiology, diagnosis, and treatment.

Connexins: A Guide is a practical and valuable reference and text covering a wide scope of information about the connexin family of membrane channel proteins.

Cancer chemotherapy can be traced back to the 1940's and since then the world has witnessed the discovery and the important application of several new drugs.

This volume is the third edition of a monograph series that was first published in 1983.

Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression.

Basic Principles of Forensic Chemistry is designed to provide a clear and concise understanding of forensic chemistry.

Rapid growth of the "e;proteomics"e; field during the past twelve years has c- tributed to significant advances in science.

Herbal Products: Toxicology and Clinical Pharmacology, Second Edition builds upon the informative foundation laid by its predecessor.

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application.

I want to thank all who contributed to this first edition for their hard work and professionalism, and especially for their patience.

Although the specimen of choice in the US drug testing industry is urine, and serum in clinical medicine, interest has recently grown in the use of other matrices as drug testing media.

Transforming Growth Factor-jl in Cancer Therapy, Volume I: Basicand Clinical Biology The present volume brings together a wealth of information that is fundamental to understanding the roleofTGF-~ in the pathogenesis, prevention, and treatment of cancer.

Although there are many pharmacology texts, and electronic sources of drug information relating to GI disorders, they are frequently encyclopedic, and practical information can be difficult to find.