Pharmacology

The Preparation of Solutions Isoosmotic with Blood, Tears, and Tissue provides the data needed to establish rules in the formulation of extemporaneous isoosmotic eye preparations for use in the new Danish Pharmacopoeia.

Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing.

oltage-gated calcium channels are essential mediators of a range of physiological functions, including the communication between nerve Vcells, the regulation of heart beat, muscle contraction, and secretion of hormones such as insulin.

Medicinal plants and their derived products remain as an indispensable source of bioactive molecules that serve as either drug candidates or lead compounds for drug design and discovery.

Circulation of blood is vital for the survival of vertebrates, including man.

Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products.

This book illustrates the role of photoprotective and radioprotective metabolites from natural sources.

The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al.

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.

For more than five decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to date information on a wide range of developments in chromatographic methods and applications.

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind.

Remarkable research has yielded whole genome data in plants, resulting in the documentation of an ever-increasing number of genes, without establishing their functions.

For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics.

Toxicological Effects of Veterinary Medicinal Products in Humans is the first definitive guide to discuss the adverse effects of veterinary medicinal products in humans.

Psychopharmaka sind integraler Bestandteil einer differenzierten Therapie psychischer Erkrankungen.

Inflammation in Heart Failure, edited by W.

Significant Pharmaceuticals Reported in US Patents identifies the next generation of pharmaceuticals reported in US Patents.

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues.

This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders.

This thorough edition explores numerous methodological approaches that can be extremely informative for our understanding of the developmental toxicant mechanisms, characterization of developmental outcomes, and development of potential interventions that are clinically relevant.

Allergens in food and their detection, management and elimination constitute a key issue for food manufacturers, especially in terms of safety.

Most medicines have never been adequately tested for safety and efficacy in pediatric populations and preterm, infants and children are particularly vulnerable to adverse drug reactions.

The first edition of Pharmaceutical Extrusion Technology, published in 2003, was deemed the seminal book on pharmaceutical extrusion.

This book is the 11th volume of the popular series "e;Medicinal and Aromatic Plants of the World"e;.

The purpose of this dictionary is to provide a convenient and affordable personal desk reference resource.

This book gathers a series of pivotal papers on the development of an HIV/AIDS vaccine published in the last two decades.

Progress in Medicinal Chemistry, Volume 59, provides a review of eclectic developments in medicinal G139 chemistry.

Handbook of Novel Psychoactive Substances (NPS) provides a comprehensive overview of the challenges that clinicians face when dealing with NPS and discusses how the profile of patients and their socio-demographic characteristics frame the serious public health concern that NPS pose.

Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of research on neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction.

Annual Reports in Medicinal Chemistry

Hair analysis is a reliable and widely used tool to evaluate drug exposure in many fields, including workplace testing, drug abuse history and withdrawal control, post-mortem toxicology, doping control, therapeutic drug monitoring of pharmaceuticals and even environmental exposure to toxic agents.

This unique volume provides the reader with an outline of ancient Egyptian civilization, history and culture.

Glutamate receptors are critically important for normal brain function.

This new volume provides a plethora of new information about potential medicinal herbs and their usefulness in treating diabetes and neurological diseases.

This highly successful textbook, acclaimed for its comprehensiveness, accuracy, and its many excellent illustrations and photographs now comes in its second edition.

Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS.

Edited by two renowned medicinal chemists who have pioneered the development of personalized therapies in their respective fields, this authoritative analysis of what is already possible is the first of its kind, and the only one to focus on drug development issues.

Phycotoxins are a diverse group of poisonous substances produced by certain seaweed and algae in marine and fresh waters and are important to the scientific community for many reasons, the most obvious being that they pose food safety issues which requires a large investment to regularly monitor the presence of these compounds in foods.

Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients.

Emerging Nanotechnologies for Diagnostics, Drug Delivery and Medical Devices covers the modern micro and nanotechnologies used for diagnosis, drug delivery, and theranostics using micro, nano, and implantable systems.

This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives.

In the past decade, we have experienced an explosion of new information about cancer therapeutic targets.

Up to the last decade or so, most general modeling approaches to the study of molecular components of biological responses have required significant amount of computer time, expertise, and resources, as well as highly specialized and often custom-written programs.

Good clinical practice (GCP) is a set of internationally recognized ethical and scientific quality requirements that must be followed when designing, conducting, recording, and reporting trials that involve the participation of human subjects.

Research on, and interest in, red blood cell formation spans several centuries and was thought to have peaked in the 1980s with the cloning of the eryth- poietin (EPO) gene.

The Side Effects of Drugs Annual was first published in 1977.

A widespread appreciation for the role that calcium plays in cell physiology and patho- physiology has now been achieved due to the pioneering studies of many of the scientists who attended the VIIth International Spring Symposium on Health Sciences at George Washington University in Washington, D.