This book explores well-established and emerging conjugation strategies that are relevant for proteins used in the field of precision medicine, focusing on techniques that are suitable for antibodies, antibody-fragments such as Fabs, scFvs, or nanobodies, scaffold proteins such as FN3 or DARPin, peptides, or model proteins.
Understanding Antiepileptic Drugs enhances patient knowledge and to acts as a facilitator to fill a significant gap in patient-physician communication in the field of epilepsy.
Die Bedeutung der Hypertonie als der häufigsten Herzkreislauferkrankung mit schwerwiegenden Folgen wurde erst in der zweiten Hälfte unseres Jahrhunderts erkannt.
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes.
This European Society of Cardiology (ESC) Handbook on Cardiovascular Pharmacotherapy has been developed by experts from the ESC Working Group on Cardiovascular Pharmacotherapy.
This book offers a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various disorders.
Interest and information in the field of medical toxicology has grown rapidly, but there has never been a concise, authoritative reference focused on the subjects of natural substances, chemical and physical toxins, drugs of abuse, and pharmaceutical overdoses.
A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME).
In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced.
Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations.
Medicinal Chemistry of Tick-Borne Encephalitis, Volume 58 in the Annual Reports in Medicinal Chemistry serial, highlights new advances in the field, with this new volume presenting interesting chapters on the Discovery of small molecule TBEV antivirals, Perylene as a controversial antiviral scaffold, Animal models of TBEV infection for preclinical studies of drugs and vaccines, Insights from experience in the treatment of tick-borne bacterial co-infections with tick-borne encephalitis, Small molecule-based inhibitors of flaviviral RNA-dependent RNA-polymerase: prospective candidates for treatment of tick-borne encephalitis virus infection, and Structural Biology and Proteomics of Tick-Borne Encephalitis Virus.
Side Effects of Drugs Annual: A Worldwide Yearly Survey of New Data in Adverse Drug Reactions, Volume 46, first published in 1977, presents clinicians and medical investigators with a critical survey of new data and trends in adverse drug reactions and interactions.
Practical Biostatistics: A Step-by-Step Approach for Evidence-Based Medicine, Second Edition presents a complete resource of biostatistical knowledge meant for health sciences students, researchers and health care professionals.
In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation.
The concept of immunotherapy was in infancy when the first edition was written; since then, major advances have been made, not only with several prominent clinical trials, but also with the approval of cell-based therapy by the FDA for the treatment of cancer in 2010.
Isocoumarin, Thiaisocoumarin and Phosphaisocoumarin: Natural Occurrences, Synthetic Approaches and Pharmaceutical Applications gives an overview of the various aspects of this class of heterocycle, with a major focus on synthesis and biological activity.
This innovative volume introduces Trajectory Analysis, a new systems-based approach to measuring nonlinear dynamics in continuous change, to public health and epidemiology.
In questi ultimi anni la popolarità dell’aloe ha conosciuto un notevole incremento: a parte l’uso tradizionale di questa pianta e dei suoi preparati come lassativo, è interessante chiedersi se questa droga vegetale possegga altre proprietà farmacologiche, la cui fama ha portato addiritura a definirla una miracle plant o wonder drug.
Theoretical and Computational Photochemistry: Fundamentals, Methods, Applications and Synergy with Experimental Approaches provides a comprehensive overview of photoactive systems and photochemical processes.
This new volume, Natural Polymers for Pharmaceutical Applications, Volume 1: Plant-Derived Polymers, presents some of the latest research on the applications of natural polymers in drug delivery and therapeutics for healthcare benefits.
Dosage Form Design Parameters, Volume II, examines the history and current state of the field within the pharmaceutical sciences, presenting key developments.
To create a forum for scientists and clinicians interested in degenerative retinal diseases, we began in 1984 to organize a biennial symposium on Retinal Degeneration as a satellite meeting of the International Congress of Eye Research.
Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption.
While acid-base indicators continue to find new applications in an ever-widening range of scientific disciplines, there is no current book that focuses entirely on the subject, nor one that brings together the relevant advances that have evolved over the last three decades.
This thought-provoking book examines how the accumulated knowledge on past and present environmental issues and risks within Japan can be applied in order to help deliver the transformation to a sustainable and well-being society.
Alzheimer's disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition.
Covers powerful new tools for drug development Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality.
Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery.
This fully updated third edition of the encyclopedia covers all aspects of pharmacology, from the chemistry of drugs and the biochemistry of drug targets to the clinical application of drugs, with emphasis on molecular mechanisms.
