Pharmacology

This is the first resource to provide researchers in academia and industry with an urgently needed update on drug intervention against trypanosomatides.

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment.

Tailored to the needs of scientists developing drugs, chemicals, cosmetics and other products this one-stop reference for medicinal chemists covers all the latest developments in the field of predictive toxicology and its applications in safety assessment.

Drug design is a complex, challenging and innovative research area.

Drug design is a complex, challenging and innovative research area.

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine.

Written for drug developers rather than computer scientists, this monograph adopts a systematic approach to mining scientifi c data sources, covering all key steps in rational drug discovery, from compound screening to lead compound selection and personalized medicine.

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide.

Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide.

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.

Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism.

Im zweiten Band dieses modular aufgebauten Lehrbuchs wird die Exposition und toxische Wirkung der wichtigsten toxischen Chemikalien
abgehandelt.

Perfekt abgestimmt auf die moderne Ausbildung zum Toxikologen, werden in diesem Lehr- und Prüfungsbuch alle wichtigen Konzepte und wissenschaftlichen Grundlagen der Toxikologie erklärt: von der molekularen Toxikologie bis hin zu Risk Assessment und Epidemiologie.

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery.

Most of the antibiotics now in use have been discovered more or less by chance, and their mechanisms of action have only been elucidated after their discovery.

This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals.

This third volume in the successful 'Drug Discovery in Infectious Diseases' series is the first to deal with drug discovery in helminthic infections in human and animals.

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.

Treating protein-protein interactions as a novel and highly promising class of drug targets, this volume introduces the underlying strategies step by step, from the biology of PPIs to biophysical and computational methods for their investigation.

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body.

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties.

In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties.

Written in a clear and concise style by an experienced author, this attractively-priced book covers regulatory affairs in all major global markets for pharmaceuticals and medical devices, making it the most comprehensive in its field.

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "e;bench to bedside"e; translational approach to drug development.

Filling a real knowledge gap, this handbook and ready reference is both modern and forward-looking in its emphasis on the "e;bench to bedside"e; translational approach to drug development.

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses.

By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses.

Im zweiten Band dieses modular aufgebauten Lehrbuchs wird die Exposition und toxische Wirkung der wichtigsten toxischen Chemikalien
abgehandelt.

Perfekt abgestimmt auf die moderne Ausbildung zum Toxikologen, werden in diesem Lehr- und Prüfungsbuch alle wichtigen Konzepte und wissenschaftlichen Grundlagen der Toxikologie erklärt: von der molekularen Toxikologie bis hin zu Risk Assessment und Epidemiologie.

Smoking causes and contributes to a large number of human diseases, yet due to the large number of potentially hazardous compounds in cigarette smoke -- almost 5,000 chemicals have been identified, establishing the link between smoking and disease has often proved difficult.

Smoking causes and contributes to a large number of human diseases, yet due to the large number of potentially hazardous compounds in cigarette smoke -- almost 5,000 chemicals have been identified, establishing the link between smoking and disease has often proved difficult.

This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites.

This handbook is the first dealing with the discovery of drugs directed against apicomplexan parasites.

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design.

This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design.

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response.

This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology.

Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response.

A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook provides systematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body.

This first comprehensive treatment of the subject for more than a decade includes the latest research on nanoparticle toxicology.

By covering the full spectrum of topics relevant to peptidic drugs, this timely handbook serves as an introductory reference for both drug developers and biomedical researchers interested in pharmaceutically active peptides, presenting both the advantages and challenges associated with this molecular class.

Written by a leading expert on Aspirin-related research, this is the first comprehensive treaty of the history, pharmacological effects and clinical applications of one of the most successful drugs ever.

Written in a clear and concise style by an experienced author, this attractively-priced book covers regulatory affairs in all major global markets for pharmaceuticals and medical devices, making it the most comprehensive in its field.

This first systematic overview for more than a decade is tailor-made for the medicinal chemist.

Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism.

This work represents the first comprehensive publication in the innovative field of pharmacogenomics, a field which is set to revolutionize pharmaceutical research.

The use of powerful computers has revolutionized molecular design and drug discovery.

In keeping with the outstanding importance of lipophilicity in biosciences, this volume examines all its facets in more than twenty contributions from leading experts.

Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds.

This unique handbook provides a comprehensive survey of the present status of Technetium chemistry and its radiopharmaceutical applications.