Pharmacology

IX The International Seminar on the Immunological System as a Target for Toxic Damage was held at The Commission of the European Communities (CEC) in Luxembourg on 6-9 November 1984.

The contents of this volume are based upon presentations made to the Second European Symposium on Radiopharmacy and Radiopharmaceuticals which was held in St.

With the emergence of the biological sciences in the seventeenth and eighteenth centuries, some explanations of congenital malformations with a basis in scientific fact were formulated.

The third congress ofthe European Association for Veterinary Pharmacology and Toxicol- ogy (EAVPT) was held in Ghent, Belgium, from 25 to 29 August 1985.

A.

High blood pressure (BP) (with fats and smoking) is one of the three roots of cardio-cerebro-renovascular disease affecting up to 25% of the adult population.

Over the past few years, research in the field of quantitative structure-activity relationships (QSAR) in chemistry, biology, pharmacology, toxicology, and environmental sciences has seen strong growth.

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The third CMR Workshop prov.

Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents.

The 20th Anniversary of a Learned Society is a momentous event in its af- fairs, and it is fitting that, in the Appendix to the Proceedings of the 20th An- niversary Meeting, the history of the Society for Drug Research is outlined.

The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins.

In recent years both doctors and patients have become increasingly aware that many essential drugs may induce unfortunate side-effects in susceptible individuals.

Over the past several decades, vanadium has increasingly attracted the interest of biologists and chemists.

Theodore H.

This volume represents the proceedings ofthe invited lectures ofthe first International Symposium on "e;Serotonin from Cell Biology to Pharmacology and Therapeutics"e; which was held in Florence on March 29 -Aprill, 1989.

Scientists are coming under increasing pressure from activist groups to stop animal experimentation, branded as cruel and unnecessary for improving human health.

Regulatory review is the last major development hurdle that must be passed by a new medicine before it reaches the market.

The original series, Advances in Prostaglandin Research, edited by Sultan M.

At present we may be at the cross-roads in the therapeutic approaches we have for the treatment of the 100 or more rheumatic conditions.

single toxicant before it, yet one that has now been brought under effective control-at least in estuaries and the nearshore environment.

Over the last decade, high performance Capillary electrophoresis (HPCE) has emerged as a powerful and versatile separation technique that promises to rival high performance liquid chromatography when applied to the separation of both charged and neutral species.

This second edition has been designed to monitor the progress in develop- ment over the past few years and to build on the information given in the first edition.

Cyclosporin has had a remarkable effect on clinical organ transplantation.

As 1992 looms on the horizon and preparation is made for the completion of the internal market in Europe, the CMR realised the value of addressing some of the issues involved and defining the objectives and achievements of medicines regulations in a number of EEC countries in comparison with Japan and the USA.

These four volumes comprising "e;GnRH Analogues in Cancer and Human Reproduction"e; are a distillation of the presentations of the invited speakers at a landmark International Symposium bearing the same name, organized by one of us (B.

These four volumes comprlslng "e;GnRH Analogues in Cancer and Human Reproduction"e; are a distillation of the presentations of the invited speakers at a landmark International Symposium bearing the same name, organized by one of us (B.

Many of the most effective treatments for disease have been discovered empir- ically.

Most of the anti-cancer drugs in use today were discovered by happy accident rather than design, yet the rational design of better anti-cancer drugs remains a cherished goal, and one of the most important challenges facing medical science.

Radiophannaceuticals labeled with short-lived radionuclides are utilized to unravel biochemical processes, and to diagnosis and treat diseases of the living body are-developed through extensive evaluation in ~iological models.

Over the past 50 years a wide variety of antibacterial substances have been discovered and synthesised, and their use in treating bacterial infection has been spectacularly successful.

In some countries such as the United States, kidney disease kills more people than cancers of the prostate or breast.

The well-being of humankind is dependent upon advances in biological and clinical sciences.

There are many conditions that affect the skeletal system.

The World Health Organisation have reported that each year on a global basis there are over 8 million deaths from cancer.

On an annual basis, over 17 million people die due to cardiovascular disease.

There are numerous types of liver disease that may be due to toxic agents (such as alcohol or drugs), infectious agents including viruses, congenital conditions and even poor dietary patterns.

The present work is a fine contribution to the broad field of environmental security in the context of risk assessment and management of obsolete pesticides for the region of Southeast Europe.

Initially, because of the inadequate sensitivity of devices and other limitations, only major venom components of the dominant species were studied.

Scorpions have fascinated humans for a long time, first and foremost because of the harm the sting of a few species could cause but also due to their unique natural history and for the many biologically active compounds found in their venoms.

Clinical toxinologic conditions are becoming increasingly frequent, more so than is generally recognized.

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases.

This book would combine chapters written by the most qualified authors around the world whose research encompasses the effect of morphine or other opioids on tumor growth and metastasis.

The modern unhealthy diet and lifestyle in conjunction with pathogens, environmental carcinogens and multiple other risk factors increase humans' susceptibility to different diseases exemplified by elevated levels of cancers, cardiovascular and communicable diseases.

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress.

The probability for exposure to damaging radiation, toxic chemicals in the environment and adverse biological agents has increased exponentially today.

"e;Molecular Pharmacognosy"e; discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM).