Medical research

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing.

Vulnerable plaque development is the result of a complex series of molecular and cellular events involving inflammation, apoptosis, rupture, and thrombosis.

Drug development is risky business.

Examining how to maintain assured quality in clinical trial research, A Practical Guide to Quality Management in Clinical Trial Research provides solid foundations, tips, and techniques for establishing a quality system that will comply with the relevant regulations.

An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson's Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD.

A comprehensive guide for physicians conducting clinical research, this second edition addresses a broader research perspective.

Assembling, reviewing, and synthesizing state-of-the-art information on translational research and therapies of melanoma into one convenient source, Melanoma: Translational Research and Emerging Therapies provides clinicians and researchers the necessary context and perspective to intergrate and effectively deploy cutting-edge therapies into daily

Due to a worldwide need for lower cost drug therapy, use of generic and multi-source drug products have been increasing.

Evidence from randomized controlled clinical trials is widely accepted as the only sound basis for assessing the efficacy of new medical treatments.

Continuing advances in biomedical research and statistical methods call for a constant stream of updated, cohesive accounts of new developments so that the methodologies can be properly implemented in the biomedical field.

Written for practitioners in both the drug and biotechnology industries, this handbook carefully compiles the current regulatory requirements to correctly and properly validate a new or modified analytical method.

During the last few years, exciting new insights into mechanisms and treatment of stroke have been obtained from animal experiments.

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition.

In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified.

Top Investigators Explore the Complexities of Angiogenesis Cancer ResearchThe targeting of tumor angiogenesis has evolved into one of the most widely pursued therapeutic strategies.

Reveals important new results from clinical trials conducted in Scandinavia, Scotland, Australia, Canada, and the United States.

This blue-chip guide adds quality to the pharmaceutical clinical development process by detailing the need for, and stressing the importance of, an independent audit of clinical data to protect participants and validate study results.

Medecines douces, medecine scientifique : des rapports conflictuels.

Adequate health and health care is no longer possible without proper data supervision from modern machine learning methodologies like cluster models, neural networks, and other data mining methodologies.

This collection presents up-to-the-minute qualitative research methodologies creatively developed by and within nursing.

This book is a joint package of a practical manual on how to undertake meta-analysis in medicine together with an accompanying CD-ROM.

Congenital malformations are worldwide occurrences striking in every condition of society.

In clinical medicine appropriate statistics has become indispensable to evaluate treatment effects.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures.

Residues from agriculture and the food industry consist of many and varied wastes, in total accounting for over 250 million tonnes of waste per year in the UK alone.

Observations Plus Recipes It has been said that science is the orderly collection of facts about the natural world.

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures.

Epigenetic modifications act on DNA and its packaging proteins, the histones, to regulate genome function.

Obesity has reached epidemic proportions globally and presents a major challenge to policy makers and clinicians alike.

"e;There is hardly a reason to circumcise a little boy for medical reasons because those medical reasons don't exist"e;, said Dr.

Nonlinear dynamics has become an important field of research in recent years in many areas of the natural sciences.

The truth is, few people know the first thing about clinical research.

Lipids are functionally versatile molecules.

Phase transitions occur throughout nature.

Johannes Klumpers Biotechnologies, such as genetic engineering, cloning and biodiversity, raise many legal and ethical concerns, so it is important that people understand these issues and feel able to express their opinions.

Proteins lie at the heart of almost all biological processes and have an incredibly wide range of activities.

Current state of knowledge and gaps in experimental evidence related to the physiologic role and toxicity of trace elements in human health were presented and discussed at an international joint conference in Hersonissos, Crete-Greece, in October 2007.

Surprisingly what separates us from the open environment all around us sometimes is a single layer of epithelial cells.

With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge.

Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction.

The "e;Groupe International de Recherche sur l'Infinitesimal"e; (GIRI) was created in 1986 by Professor Madeleine Bastide and Doctor Rene Halm.

Is it acceptable from an ethical point of view to use stem cells from human embryos for scientific research and clinical therapy?

"e;Nanomaterials and Nanosystems for Biomedical Applications"e; brings together under a single cover various aspects of functional bioengineered materials and nanostructured biomaterials including commonly used implants and sustained release nanodevices.

Kary Mullis was awarded a Nobel Prize for inventing the PCR technique more than 15 years ago in 1993.

Cancer genetics is a field of daunting breadth and depth.

Retinal and choroidal angiogenesis are the leading causes of irreversible vision loss in developed countries.

Skeletal muscle is the most abundant tissue of our body.

Cancer cells are continuously interacting with the immune system of the host.