Medical research

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases.

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved.

This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases.

This edited book explores the use of technology to enable us to visualise the life sciences in a more meaningful and engaging way.

Together with Volume 1, this book provides an inclusive overview of the molecular and cellular mechanisms of carcinogenesis and offers comprehensive insights into related clinical and therapeutic aspects.

Divided into two volumes the work offers a so far unmatched broad and at the same time deep knowledge on molecular and cellular mechanisms of carcinogenesis and offers comprehensive insight into clinical, therapeutic and technological aspects.

The second of two companion books which address the biology and clinical aspects of prostate cancer.

This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart.

In this book, leading international experts analyze state-of-the-art advances in gene transfer vectors for applications in inherited disorders and also examine the toxicity profiles of these methods.

The eukaryotic gene expression pathway involves a number of interlinked steps, with messenger RNA (mRNA) being the key intermediate.

This book provides a practical guide to the analysis of data from randomized controlled trials (RCT).

This extensively revised new edition comprehensively reviews the rise of clinical research informatics (CRI).

This essential book details intermediate-level statistical methods and frameworks for the clinician and medical researcher with an elementary grasp of health statistics and focuses on selecting the appropriate statistical method for many scenarios.

This book draws a unique perspective on the regulation of access to clinical trial data as a case on research and knowledge externalities.

This book represents an up-dated summary of the state of the art of the characterization of cancer stem cell/ cancer initiating cell (CSC/CIC) properties.

The "e;world"e; of soft tissue sarcomas is a highly complex one, due to the large range of tumor types, each of which is characterized by specific features in terms of its epidemiology, pathology diagnosis, clinical behavior, therapy and biomarker pattern (of both diagnostic and therapeutic value).

This book is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in immunotherapy.

Nuclear receptors are ligand activated transcription factors that control numerous biological functions.

This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments.

This textbook aims to describe the fascinating area of eukaryotic gene regulation for graduate students in all areas of the biomedical sciences.

This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis.

This book reaches out to a wide variety of professionals in the biomedical field with an interest in inflammatory bowel disease (IBD).

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing.

This monograph covers a novel technology to deliver drugs and cosmetics through the skin in a minimally invasive manner.

This volume presents a new contribution for the field of Tissue Engineering with a focus on the development of mathematical and computational methods that are relevant to understand human tissues, as well to model, design, and fabricate optimized and smart scaffolds.

This comprehensive text examines both global and local coronary blood flow based on morphometry and mechanical properties of the coronary vasculature.

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications.

Parents can easily be bombarded by conflicting messages about vaccines a dozen times each week.

How liberal democracies in the late twentieth century have sought to resolve public concerns over charged issues in medicine and science.

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry.

Curcumin for Neurological and Psychiatric Disorders: Neurochemical and Pharmacological Properties focuses on the different molecular mechanisms underlying curcumin-mediated beneficial effects in neurological diseases.

A Comprehensive and Practical Guide to Clinical Trials provides an overview of the entire process of clinical research in one thorough and easy-to-read handbook that offers those involved in clinical research a clear understanding of how the components of a study are related.

The combination of faster, more advanced computers and more quantitatively oriented biomedical researchers has recently yielded new and more precise methods for the analysis of biomedical data.

The biological function of clusterin (CLU, also known as ApoJ, SGP2, TRPM2, CLI) has been puzzling researchers since its discovery and characterization in the early 1980s.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research.

Academic Press proudly presents this Cumulative Subject Index covering Volumes 50-72 of Advances in Cancer Research.

This book discusses the two different cellular approaches that are pursued in regenerative medicine: cell therapy and tissue engineering.

This book discusses managing SOPs for GCP from conception to retirement.

National Science Foundation (NSF) is a unique federal agency because it supports scientific research financially, but does not engage in scientific work itself.

Understanding the molecular mechanism of muscle contraction started with the discovery that striated muscle is composed of interdigitating filaments which slide against each other.

The growth of the pharmaceutical industry over the past decade is astounding, but the impact of this growth on statistics is somewhat confusing.

Intensive Care for Neurological Trauma and Disease presents the progress in intensive care in terms of technological development on life-support and monitoring systems.

The management of clinical data, from its collection during a trial to its extraction for analysis, has become critical in preparing a regulatory submission and obtaining approval to market a treatment.

The world-renowned experts at JAMA(R) explain statistical analysis and the methods used in medical research Written in the language and style appropriate for clinicians and researchers, this new JAMA Guide to Statistics and Methods provides explanations and expert discussion of the statistical analytic approaches and methods used in the medical research reported in articles appearing in JAMA and the JAMA Network journals.

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

This volume discusses methods used in the fields of molecular and cellular biology for detecting and studying cell death, especially in cancer and cancer therapy.

This fully revised new edition explores advances in the prevention and treatment of oral diseases.