Medical research

This book is a comprehensive exploration of the multifaceted role of phytochemicals in contemporary drug discovery and biotechnology.

This book is a comprehensive compilation of over 100 natural and alternative cancer treatments.

This edited book contains chapters that describe bespoke three-dimensional (3D) printing aimed at democratizing anatomy education by providing open-source scans for download and printing as 3D models.

Post-Concussion Syndrome: An Evidence Based Approach surveys the research on this disorder.

This volume provides an introduction to the process of clinical drug development.

Praise for the first edition:"e;Given the author's years of experience as a statistician and as a founder of the first DMC in pharmaceutical industry trials, I highly recommend this book-not only for experts because of its cogent and organized presentation, but more importantly for young investigators who are seeking information about the logistical and philosophical aspects of a DMC.

Highly recommended by CHOICE, Oct 2018Extremophiles are nature's ultimate survivors, thriving in environments ranging from the frozen Antarctic to abyssal hot hydrothermal vents.

Mathematical and Statistical Skills in the Biopharmaceutical Industry: A Pragmatic Approach describes a philosophy of efficient problem solving showcased using examples pertinent to the biostatistics function in clinical drug development.

Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a comprehensive introduction to statistical methodology for the evaluation and discovery of dynamic treatment regimes from data.

Review of the First Edition"e;The goal of this book, as stated by the authors, is to fill the knowledge gap that exists between developed statistical methods and the applications of these methods.

In recent years, many pharmaceutical companies and clinical research organizations have been focusing on the development of traditional Chinese (herbal) medicines (TCMs) as alternatives to treating critical or life-threatening diseases and as pathways to personalized medicine.

Fundamental Concepts for New Clinical Trialists describes the core scientific concepts of designing, data monitoring, analyzing, and reporting clinical trials as well as the practical aspects of trials not typically discussed in statistical methodology textbooks.

Cancer is a major healthcare burden across the world and impacts not only the people diagnosed with various cancers but also their families, carers, and healthcare systems.

Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials.

There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases.

Clinical Trial Optimization Using R explores a unified and broadly applicable framework for optimizing decision making and strategy selection in clinical development, through a series of examples and case studies.

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach.

Cluster Randomised Trials, Second Edition discusses the design, conduct, and analysis of trials that randomise groups of individuals to different treatments.

All the Essentials to Start Using Adaptive Designs in No TimeCompared to traditional clinical trial designs, adaptive designs often lead to increased success rates in drug development at reduced costs and time.

Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials.

Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials.

In a global clinical development strategy, multiregional clinical trials (MRCTs) are vital in the development of innovative medicines.

Develop Effective Immunogenicity Risk Mitigation StrategiesImmunogenicity assessment is a prerequisite for the successful development of biopharmaceuticals, including safety and efficacy evaluation.

This volume summarizes research and treatment on focal neuropathies to update clinicians on nerve biology and new diagnostic techniques to guide investigation and treatment of mononeuropathies.

This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals.

This text for advanced undergraduate and graduate students covers the fundamental relationships between the structure and properties of materials and biological tissues.

This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals.

Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications.

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date.

This book addresses electron spin-qubit based quantum computing and quantum information processing with a strong focus on the background and applications to EPR/ESR technique and spectroscopy.

This book discusses the molecular, biological, pathological, and clinical aspects of melanoma, with special emphasis in the new concepts of melanoma genetics.

This text provides a comprehensive, state-of-the-art review of the application of image analysis focusing on the techniques which can be used in every biology and medical laboratory to automate procedures of cell analysis and to create statistics very useful for a comprehension of cell growth dynamics and the effects of drugs on them.

This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management.

This volume is a concise yet comprehensive resource for physicians dealing with, and interested in, the field of molecular pathology in dermatopathology.

This volume describes chemical approaches to assess ion channel structure, function and pharmacology.

This book is unique in covering a wide range of design and analysis issues in genetic studies of rare variants, taking advantage of collaboration of the editors with many experts in the field through large-scale international consortia including the UK10K Project, GO-T2D and T2D-GENES.

"e;Biobetters: Protein Engineering to Approach the Curative"e; discusses the optimization of protein therapeutic products for treatment of human diseases.

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections.

Tissue diagnosis in surgical pathology is the most important determinant of patient outcomes in oncology and other medical conditions.

This volume explores the application of Quality by Design (QbD) to biopharmaceutical drug product development.

In the past two decades we have seen a surge forward in understanding the genetics and biochemistry underlying many pediatric orthopaedic disorders.

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The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions.

This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms.

This volume provides a compact, concise and up-to-date resource for pathologists and clinicians who are involved in women's health.

This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis.

This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research.

Mitochondria, often referred to as the "e;powerhouses"e; of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis.

Reproductive biology is more than the development of techniques for helping with too little or too much breeding.