This volume focuses on target-oriented approximations to drug discovery, including target selection, binding pocket detection, and current uses and variants of molecular dynamics and molecular docking.
Telling the story of a clinical trial testing an innovative gel designed to prevent women from contracting HIV, Negotiating Pharmaceutical Uncertainty provides new insight into the complex and contradictory relationship between medical researchers and their subjects.
This book presents vital information on international sterilization standards and guidance on practical application of these standards in the manufacturing process.
Target pattern recognition in innate immunity is responsible for the immediate, usually protective, responses shown against invading microorganisms, and it is the principal feature of self and non-self recognition by virtue of the recognition of structures on the microbial pathogens, which are not found on host cells.
The Third Edition of Arlene Fink’s Evaluation Fundamentals teaches the basic concepts and vocabulary necessary to do program evaluations and review the quality of evaluation research to make informed decisions about methods and outcomes to meet scientific and community needs.
This extensive book brings together leading melanoma researchers from across the world and highlights many of the cutting-edge protocols and experimental systems currently being used to investigate questions surrounding this disease.
The book investigates digitalisation in care for older people by giving insight into service users' and professionals' opportunities to digital agency in the context of European welfare states.
This book offers an extensive overview of the current and future potential of polysaccharides-based films, providing in-depth coverage of the fundamentals and basics of polysaccharide-based films.
Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint.
This title covers recent advances in a variety of biomedical applications of nanostructured materials, as the field evolves from prototype device to real-world application.
Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety.
Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind.
The development of biodegradable implants which can remain in the human body to fix a problem and subsequently dissolve, or be absorbed, consumed or excreted, without warranting a secondary surgery, is very appealing to scientists.
In the last three decades, the fast development of single-molecule techniques has revolutionized the way we observe and understand biological processes.
Statistical methods that are commonly used in the review and approval process of regulatory submissions are usually referred to as statistics in regulatory science or regulatory statistics.
That residues of pesticide and other "e;foreign"e; chemicals in food- stuffs are of concern to everyone everywhere is amply attested by the reception accorded previous volumes of "e;Residue Reviews"e; and by the gratifying enthUSiasm, sincerity, and efforts shown by all the individ- uals from whom manuscripts have been solicited.
Dieser Band in der Reihe "Naturwissenschaften Bibliothek" zeigt an einigen ausgesuchten Beispielen, vorgestellt im Rahmen des Studium Generale an der Universität Marburg, wie sich Irrtümer in der Wissenschaft ereignen können, welche - teilweise fruchtbaren - Auswirkungen sie haben können, und welche Konsequenzen sich aus der Fehlbarkeit der Wissen- schaftler ergeben sollten.
Biosurfactants and bioemulsifiers are considered green molecules as they are produced from microbes and are easily degradable as compared to surfactants.
Asthma: Physiology, Immunopharmacology, and Treatment is a collection of essays that discusses the clinical signs and symptoms of allergic bronchial asthma and the effects of a number of intricate sequences of biochemical reactions initiated by the combination of antigen and antibody.
This contributed volume applies the insights of supramolecular chemistry to biomedical applications such as ions/water transport through nano-scale channels, gene therapy, tissue engineering and drug delivery, to cite some of the major investigations.
Die weltweit renommierte Virologin Isabella Eckerle über die Sprengkraft von Virus-Infektionen - ein hochaktuelles Wissenschafts-Sachbuch über Zoonosen, Pandemien und die globale Gesundheit.
The book summarizes the emerging topic about the effects of SMF on biological samples ranging from single molecules, subcellular compartments, and cells to whole organisms.
In this congressionally mandated study, an expert committee of the Institute of Medicine takes a close look at where treatment for people with alcohol problems seems to be headed, and provides its best advice on how to get there.
Retrieval Medicine is a core, concise and practical text covering the complex clinical and logistical problems experienced in the retrieval environment.
For several years, researchers have been reporting the effects of microwave radiation/heating on both the structure and function of DNA, RNA and proteins.
Explores the evidence for collaboration-based approaches to improving healthcare, focusing on quality improvement collaboratives and communities of practice.
Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials.
This book contains most of the scientific contributions during the 48th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), which was held electronically in July 2021.
When 18-year-old Jesse Gelsinger died in a gene transfer study at the University of Pennsylvania, the national spotlight focused on the procedures used to ensure research participants' safety and their capacity to safeguard the well-being of those who volunteer for research studies.
This comprehensive resource explains the FDA's classification of devices and provides expert guidance on differentiating between significant risk and non-significant risk medical device studies.