It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to insufficient clinical activity, unacceptable toxicity, rapid appearance of drug resistance, or other factors that should be, at least partially, predictable from preclinical testing.
This authoritative reference presents an up-to-date review of the testing methods, emerging technologies, and analytical systems and procedures used to prevent the microbial contamination of pharmaceutical processes, products, and environments.
Taking readers from the research laboratory to the bedside, this Second Edition compiles essential information on the pharmacodynamics of all major classes of the antimicrobial armamentarium including penicillins, cephalosposorins, cephamycins, carbapenems, monobactams, aminoglycosides, quinolones, macrolides, antifungals, antivirals, and emerging
Virtual screening can reduce costs and increase hit rates for lead discovery by eliminating the need for robotics, reagent acquisition or production, and compound storage facilities.
Completely revised and updated, Pharmaceutical Experimental Design and Interpretation, Second Edition explains the major methods of experimental design and evaluation such as multivariate, sequential, and principal components analysis.
The Handbook of Carbohydrate Engineering provides an overview of the basic science, theory, methods, and applications of this broad, interdisciplinary field.
Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments.
The Revolution of Modern Medicine Begins HereThe world of medicine is changing faster than ever before, and its all thanks to the unprecedented advancements brought by artificial intelligence.
The Revolution of Modern Medicine Begins HereThe world of medicine is changing faster than ever before, and its all thanks to the unprecedented advancements brought by artificial intelligence.
The broad range of G protein-coupled receptors (GPCRs) encompasses all areas of modern medicine and have an enormous impact on the process of drug development.
A Single Source on Parallel Synthesis for Lead OptimizationThe end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening.
This book comprehensively reviews the diverse potential of microbial enzymes with therapeutic applications, covering their production, purification, and utilization.
A True Insider's Guide to the Field - Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery.
This book explores key aspects of scientific reasoning, clinical methodology, and evidence-based practice, using quotes from the lectures of Jean-Martin Charcot (1825-1893) as a starting point for discussion and in-depth analysis.
This book explores key aspects of scientific reasoning, clinical methodology, and evidence-based practice, using quotes from the lectures of Jean-Martin Charcot (1825-1893) as a starting point for discussion and in-depth analysis.
Handbook of Nutritional Disorders is a comprehensive handbook covering topics in nutrition, malnutrition, and the clinical disorders associated with nutrition from deficiency to toxicity.
Sponsor companies and CROs alike will appreciate the industry-wide analysis, practical, how-to advice, and helpful charts and checklists provided by Outsourcing in Clinical Drug Development.
A fines de 1890 una noticia recorrió el mundo entero: el sabio alemán Robert Koch acababa de descubrir un remedio capaz de poner fin a la tuberculosis.
Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more.
This edited volume encompasses chapters on novel and innovative research in the applications of leading digital technologies in an accessible and engaging way.
Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable and non-implantable devices, rehabilitation, psychotherapy, and behavioral interventions.