This edited book focuses on the recent advances in our understanding of age-related macular degeneration (AMD), combining epidemiology and clinical diagnosis, with genetics and immunological aspects as well as the role of proteostasis and mitochondria before diving into new therapies including stem cell based approaches.
This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987.
Epigenetic mechanisms (DNA modifications, histone alterations and non-coding RNAs) are crucial for transcriptional regulation and alterations of the "e;physiological epigenome"e; are increasingly associated with human diseases.
Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems.
This book is the product of a NATO Advanced Study Institute of the same name, held at the Anargyrios and Korgialenios School on the island of Spetsai, Greece, in September 1994.
This innovative book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it will help mitigate the healthcare crisis and rein in ever-growing expenditure.
The goal of this book is to introduce the biological and technical aspects of next generation sequencing methods, as well as algorithms to assemble these sequences into whole genomes.
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics.
Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner.
Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists.
The controversial topic of the technology of Pre-implantation Genetic Diagnosis, and the muddled approach to this subject adopted by the UK Parliament, is explored in detail in this volume.
This book evolved from the editors strong belief that the information and new developments that were evolving from the rapidly growing field of genomics and that are happening primarily in the developed world have not happened at a parallel rate in the developing world.
Statistical Methods for Survival Trial Design: With Applications to Cancer Clinical Trials Using R provides a thorough presentation of the principles of designing and monitoring cancer clinical trials in which time-to-event is the primary endpoint.
During the first half century of genetics, coinciding with the first half of this cen- tury, geneticists dreamt of the repair of genetic disease by altering or replacing defective genes.
Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues.
This volume brings together the disciplines of plant and animal genome research, and serves as an opportunity for scientists from both fields to compare results, problems and prospects.
Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father.
Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments.
This third edition of Epstein's Inborn Errors of Development provides essays on pathways of development and thoughtful reviews of dysmorphic syndromes for which the causative gene has been identified.
For decades, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics has served as the ultimate resource for clinicians integrating genetics into medical practice.
The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology.
The OHOLO Conferences have been convened annually from the Spring of 1956; the wide areas they have covered, from different and overlapping disciplines, can be seen from the following list: 1956 Bacterial Genetics (not published) 1957 Tissue Cultures in Virological Research (not published) 1958 Inborn and Acquired Resistance to Infection in Animals (not published) 1959 Experimental Approach to Mental Diseases (not published) 1960 Cryptobiotic Stages in Biological Systems* 1961 Virus-Cell Relationships** 1962 Biological Synthesis and Function of Nucleic Acids** 1963 Cellular Control Mechanism of Macromolecular Synthesis** 1964 Molecular Aspects of Immunology** 1965 Cell Surfaces** 1966 Chemistry and Biology of Psychotropic Agents (not published) 1967 Structure and Mode of Action of Enzymes** 1968 Growth and Differentiation of Cells In Vitro** 1969 Behaviour of Animal Cells in Culture** 1970 Microbial Toxins** 1971 Interaction of Chemical Agents with Cholinergic Mechanisms** 1972 Immunity in Viral and Rickettsial Diseases*** The participants who attend these Conferences are drawn from dif- ferent scientific institutions in Israel and from many foreign countries; they are engaged in fields of study which represent widely divergent approaches to biology.
Joint hypermobility, joint laxity or "e;double-jointedness"e; is no longer regarded as just a quaint clinical entity, but has gained recognition as a feature common to a heterogeneous group of generalized hereditary connective tissue disorders.
Since the advent of the Human Genome Project, an increasing number of disease-causing genes have been discovered and, in some cases, genetic tests developed.
Hematopoietic Stem Cells brings together articles covering the biology of hematopoietic stem cells during embryonic development, reporting particular aspects of fly, fish, avian and mammalian models.
This book presents a collection of chapters, which address various contexts and challenges of the idea of human enhancement for the purposes of human space missions.
Similarities in structure and function between pigs and human beings include size, feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmo- nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory rates, tidal volumes and social behaviors.
A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don't necessarily think of evolution.
The only book available in the area of forward-time population genetics simulations applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies.
Animal biotechnology is a broad umbrella encompassing the polarities of fundamental and applied research including molecular modelling, molecular and quantitative genetics, gene manipulation, development of diagnostics and vaccines and manipulation of tissue or digestion metabolism by growth promoters.
Clinicians and scientists are increasingly recognising the importance of an evolutionary perspective in studying the aetiology, prevention, and treatment of human disease; the growing prominence of genetics in medicine is further adding to the interest in evolutionary medicine.
Proteomics is an introduction to the exciting new field of proteomics, an interdisciplinary science that includes biology, bioinformatics, and protein chemistry.
This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases.
