Medical genetics

This book presents protocols for identification of genetic drivers of cancer.

Due in part to the selective nature of telomerase inhibition as an anticancer approach, the field has expanded considerably in the past decade.

In Gene Therapy Protocols, Volumes 1 & 2, internationally recognized investigators describe cutting-edge laboratory techniques for the study of Production and In Vivo Applications of Gene Transfer Vectors (Volume 1) and Design and Characterization of Gene Transfer Vectors (Volume 2).

The rapid progression of genetics and molecular biology has turned chromosomal engineering from science fiction to reality, with the successful production of transgenic animals with engineered chromosomes and chromosomes developed for pharmaceutical protein production which are now ready for the medical industry.

The genomes of humans, as well as many other species, are interspersed with hundreds of thousands of tandem repeats of DNA sequences.

Gene correction is a technology that gives us the tools for both repairing and mutating DNA, for discovering gene functions and for engineering new genetic variants.

Since the first edition, published in 2001, genomics research has taken great strides.

This volume of Methods in Molecular Biology focuses on techniques to determine the function of a gene.

In the last decade, several different optical imaging techniques, either based on various voltage or calcium dyes, or more recently on modified fluorescent or bioluminescent proteins (genetically encoded) that are sensitive to calcium, have been developed to study neuronal activity, and especially groups of neurons, with the goal of mapping and deciphering the neural code underlying major neurophysiological functions.

This book highlights recent research investigating psychological and neural mechanisms contributing to dysfunctional cognition in people with schizophrenia.

This concise text examines the contribution of genetic research to clinical practice in colorectal cancer.

This volume presents a comprehensive collection of quick assays for the detection of nuclear and mitochondrial DNA damage and its effects in live and fixed cells and tissues, and in bacterial genomes.

This book entitled "e;Cancer Stem Cell Markers and Related Network Path-ways"e; is about cancer stem cell (CSC) markers and the molecular network pathways.

This volume provides protocols designed to study the function and the structure of diverse ribozymes.

The volume summarizes the most recent advances in our understanding of the mesentery and explains the how these are important in inflammation.

Mit zunehmendem Alter sinkt nicht nur das körperliche Leistungsvermögen, sondern auch die kognitiven Fähigkeiten des Gehirns lassen nach.

Mit zunehmendem Alter sinkt nicht nur das körperliche Leistungsvermögen, sondern auch die kognitiven Fähigkeiten des Gehirns lassen nach.

Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care.

Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care.

Der Umgang mit Menschen, welche unter Alzheimer bzw.

Metagenomics: Perspectives, Methods, and Applications provides thorough coverage of the growing field of metagenomics.

Genetic testing has provided important clues to understanding our health, but it has also raised many ethical, legal, and medical questions and concerns.

This volume provides a comprehensive overview of the experimental and computational methodologies used to study the function of long non-coding RNA (ncRNAs) expressed from enhancers.

Homing Endonucleases: Methods and Protocols aims at providing molecular biologists with a comprehensive resource to identify and characterize homing endonucleases from genomic sequence, to deduce the biological basis of binding and cleavage specificity, as well as to provide protocols to redesign endonuclease target specificity for genome-editing applications.

This book presents a comprehensive collection of detailed state-of-the-art exon skipping and splices modulation protocols.

This second edition explores up-to-date tools in various function-based technologies currently used in metagenomics.

Over the past twenty years, the development of chromatin immunoprecipitation, or ChIP, assays has immensely enhanced the biological significance of the multifaceted DNA-binding proteins.

In vitro mutagenesis remains a critical experimental approach for investigating gene and protein function at the cellular level.

Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology.

Providing a guide to classical experimental approaches to decipher splicing mechanisms and experimental strategies that rely on novel multi-disciplinary approaches, Spliceosomal Pre-mRNA Splicing: Methods and Protocols describes the theory of alternative pre-mRNA splicing in seven introductory chapters and then introduces protocols and their theoretical background relevant for a variety of experimental research.

This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases.

This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues.

Bettina Heberer gibt interessierten Laien einen Einblick in die Verwendung von Gentechnik in der Medizin.

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence.

This book provides a cutting-edge review of polyglutamine disorders.

This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics.

This Brief is devoted to the CFTR protein and cystic fibrosis, and it provides an updated perspective of the genetic, functional and cellular processes involved in this conformational disorder.

The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "e;Precision Medicine"e;.

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.

This book provides a comprehensive summary of the latest developments in the field of the genomics of cardiac disease.

There has been an enormous increase in information relating to microRNA (miRNA) and its strategic role in numerous diseases.

This book reviews the human genome from an evolutionary perspective.

This book discusses the latest research into the highly prevalent neurodevelopmental disease most commonly associated with aging: Alzheimer's disease (AD).

This book presents the state of the art in genetic eye research in Asia and the Pacific.

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases.

This comprehensive book presents a modern concept in biophysics  based on recently published research.

This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation.

This book focuses on clinical presentations that may be caused by inherited metabolic diseases.