Medical genetics

A gene is a DNA sequence that can be transcribed into an RNA molecule and transferred to offspring organisms.

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Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research.

Increasingly, primary care professionals are faced with challenges in dealing with patients who have been affected by a genetic disorder, or whose family history is of concern.

This first title on the topic provides complete coverage, including the molecular basis, production and possible biomedical applications.

Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care.

This volume details protocols that can be used for generation of knockout animals.

In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors.

The data, the information, and even the overarching knowledge necessary for risk assessments of economically important environmental carcinogens come, for the most part, from the applied biological disciplines, e.

This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research.

This volume documents our growing understanding of the human major histocompatibility complex.

The only book available in the area of forward-time population genetics simulations applicable to both biomedical and evolutionary studies The rapid increase of the power of personal computers has led to the use of serious forward-time simulation programs in genetic studies.

JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders.

This volume presents a comprehensive collection of quick assays for the detection of nuclear and mitochondrial DNA damage and its effects in live and fixed cells and tissues, and in bacterial genomes.

The aim of this book will be to contribute to the education of a new generation of experts in urology, molecular biology, pathology and oncology, offering them sufficient knowledge in basic and translational research to be fluency in the web of interacting networks playing a role in prostate cancer development, progression, metastasis and drug-resistance.

This volume provides readers with a historical foundation in standard techniques and a comprehensive update on the latest methods used in making gene-modified mice.

Teratology is at once among the oldest and youngest of human preoccupations.

PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man.

This detailed volume focuses on recent technological, computational, and biostatistical advances in the field of high-throughput metabolomics.

Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care.

Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2).

This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology.

Dieses Buch stellt das erste deutschsprachige Werk dar, in dem die neuen, grundlegenden Entwicklungen auf dem Gebiet der Molekularbiologie und Molekulargenetik vor dem Hintergrund ihrer Bedeutung für die klinische und wissenschaftliche Humanmedizin beschrieben und diskutiert werden.

This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy.

This book offers a detailed overview of translational bioinformatics together with real-case applications.

Written by global experts, this book provides a modern comprehensive insight into the pharmacogenetics of treatment of major psychoses: schizophrenia, bipolar disorder and depression.

Drugs are administered to patients with the intention of achieving an expected therapeutic response.

This volume provides broad coverage of computational and mathematical techniques and concepts related to the field of comparative genomics.

Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life.

This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores.

This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors.

Who are the Jews--a race, a people, a religious group?

Medical information science requires analytic tools.

This book deals with the research and use of embryonic stem cells to combat a number of diseases and the legal limitations, arising mostly from bioethical concerns regarding human life.

The question of how man has emerged must be as old as human thought itself.

DNA testing and its forensic analysis are recognized as the "e;gold standard"e; in forensic identification science methods.

This is a reference handbook for young researchers exploring gene and cell therapy.

The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer.

Molecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins.

This book provides an introduction to and an overview of the field of regulatory RNA, focusing on the identification of regulatory elements and motifs in such RNA molecules.

Ashkenazi Jews have the highest known population risk of carrying specific mutations in the high-risk breast cancer genes, BRCA1 and BRCA2.

since the earliest results on the linkage between ras activation and cell transformation appeared a vast amount of additional information has been generated which emphasizes the importance of ras-related genes in membrane trafficking, cell proliferation, differentiation and cancer.

In genetic pathology, epigenetic testing is rare and under utilised.

All physicians practicing medicine encounter patients suffering from cardiovascular disease.

During the decade since the publication of the first edition of this important book, there has been a rapid advancement in the techniques of genetic engineering and molecular biology.