Pre-clinical medicine: basic sciences

This volume focuses on a challenging field in biomedicine: the genetic control of central immune tolerance.

This book considers the growing popularity of solo motherhood via gamete donation and how this type of "e;cyborg conception"e; is narrated in medicine, bioethics, fiction, and memoir.

This book offers a historical perspective on the scientific milestones that have brought IVF to its current prominence and explores future directions based on ongoing research.

This book introduces different Rare Genetic Disorders (RGDs), and challenges in their diagnosis.

This volume contains twenty-six lectures on basic anatomy and physiology for first-year university students.

This book provides a concise yet comprehensive review of the morphological, biochemical, electrical, mechanical, and metabolic properties of vascular smooth muscle, the regulation of vascular activities and the intracellular signaling involved.

This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease.

This book illustrates the activities of mammalian sirtuin SIRT6 in connection with DNA damage repair and premature aging.

This book provides the latest research progress on genome editing in cardiovascular and metabolic diseases and includes bioinformatics research methodology of genome editing.

This book focuses on both high-density lipoproteins (HDL) metabolism and related diseases from the perspectives of the world-class experts in HDL.

This book presents the latest research findings on the laterality of fish and other animals.

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics.

This book gathers relatively recent and significant topics in the field of ion channel research.

This third volume, with three supporting editors, broadens its focus on genetic eye research from the Asian to the global scale.

This book presents selected papers introducing readers to the key research topics and latest development trends in the theory and application of MMESE.

This book provides a comprehensive overview of carotenoid biosynthesis by different organisms, including bacteria, archaea, fungi, arthropods, and plants.

This book provides an up-to-date review of the fundamentals of lipid metabolism and its role in cardiovascular diseases.

 This book aims to introduce the latest research in gut microbiota by systematically summarizing how it modulates the pathogenesis of organ injury including alimentary tract injury, liver injury, lung injury, brain injury, renal injury, heart and vascular injury, endocrine disorders, immune responses and multiple organ dysfunction syndrome (MODS) during sepsis.

This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models.

This volume covers the science of ALDH enzymes in relation to chronic disease processes and the future therapeutic potentials of targeting ALDH in these processes.

This book presents an overview of the recent technologies in single molecule and single cell sequencing.

This book presents the commonality and heterogeneity of the mechanisms underlying smooth muscle spontaneous activity in various smooth muscle organs and in addition discusses their malfunctions in disease and their potential as novel therapeutic targets.

This book provides a far-sighted perspective on the role of wearable and wireless systems for movement disorder evaluation, such as Parkinson's disease and Essential tremor.

This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice.

This book is designed for anyone involved in surgical education.

These proceedings showcase the best papers selected from more than 500 submissions, and introduce readers to the hottest research topics and the latest developmental trends in the theory and application of MMESE.

This book summarizes the latest advances in pain research.

The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers.

This book elucidates how advances in genomics research are being applied in connection with heart diseases.

This book provides an essential overview of the rapidly advancing field of circular RNAs - newly discovered RNAs that are generated by back-splicing precursor mRNA and perform regulatory functions in many biological processes.

This book systemically describes the mechanisms underlying the neural regulation of metabolism.

This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels.

The volume provides a review of statistical development and application in the area of human genomics, including candidate gene mapping, linkage analysis, population-based genome-wide association, exon sequencing, and whole genome sequencing analysis.

This second volume continues with a focus on the state of the art in genetic eye research in Asia and the Pacific.

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics.

This volume covers the emerging area of science, Clinical Lipidomics, which is the application of lipidology to the understanding of physiological and pathophysiological changes of lipidomes, with a special focus on lipidomic profiles in human diseases.

This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases.

Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila.

This volume in the series, Translational Bioinformatics, provides an up-to-date overview of genomic approaches to asthma.

The book introduces readers to the concept of weightlessness and microgravity, and presents several examples of microgravity research in fluid physics, the material sciences and human physiology.

Hair is a sophisticated bio-based material, whether it is on a human head or part of a mammalian coat.

The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology.

This book focuses on an "e;outside the box"e; notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology.

This volume focuses on the modulation of biological membranes by specific biophysical properties.

This book provides visionary perspective and interpretation regarding the role of wearable and wireless systems for the domain of gait and reflex response quantification.

This book addresses the developmental origins of health and disease (DOHaD), a new medical concept that demonstrates that various adult diseases start in the fetal period.

This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance.

This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS).

The book provides and intensive overview on exosomes in cardiovascular diseases, its potential as biomarkers, as well as pathological and therapeutic effects.