Pre-clinical medicine: basic sciences

Cardiovascular dynamics is a field in which modelling and systems analysis have formed an extremely important discipline.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf- ficient blood in the peripheral tissues for their metabolic demands.

Nitric oxide (NO) is a simple gas with free radical properties.

This title covers the NO research in a number of areas of medical science and practice, such as hypertension, tumor growth, critical car, hepatic surgery, geriatrics, and gynecology.

Vascular diseases, particularly atherosclerosis, are the most frequent and critical underlying fatal disorders in the industrialized world.

Gasps, sighs, and yawns are recognized by even a casual observer as involuntary expressions of emotion through the "e;medium"e; of respiration.

Cardiac performance is regulated not only by cardiac muscle properties but also by several other factors, including those associated with the neurohumoral system and the mechanical characteristics of the peripheral circulation.

This book provides a comprehensive overview of the multitude of different forms of thermotherapy in connection with aspects of thermal physiology and cell biology.

Advances in cellular physiology and molecular biology have now disclosed the metabolic changes and adaptational responses of the heart to various kinds of stresses.

Information flow as nerve impulses in neuronal circuits is regulated at synapses.

Cardiovascular fluid mechanics is now used as a tool in determining diagnosis, treatment, and prognosis by physicians and surgeons working in the fields of cardiology and angiology.

Strong body odor is a condition for which, until now, there have been few treatment methods.

At the Fifth International Neuromuscular Meeting held in Tokyo in 1994, leading experts in the field came together to discuss the physiology and pharmacology of neuromuscular receptor sites and neuromuscular blocking agents (NBAs).

At the Mie International Symposium held in Japan in April 1994, leading scientists reviewed recent advances in the understanding of the contractile mechanism in smooth muscle.

This two-volume set provides a general overview of the evolution of the human genome; The first volume overviews the human genome with descriptions of important gene groups.

This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types.

This book is the first digital atlas of the degu brain with microscopic features simultaneously in Nissl sections and magnetic resonance imaging (MRI).

This book provides accurate, comprehensive, and convenient reference for usages of the "e;freely rotatable three dimensional combined Nissl-stained and MRI digital data of the marmoset brain"e;.

This book reviews the human genome from an evolutionary perspective.

This book is dedicated to a specific component of paleoneurology, probably the most essential one: endocasts.

This book presents the state of the art in genetic eye research in Asia and the Pacific.

This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules.

This book provides readers with the most up-to-date information on cutting-edge research concerning chronic inflammation.

This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins.

This book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets.

This book describes newly developed methods of assessing the autonomic nervous system.

This book deals with computational anatomy, an emerging discipline recognized in medical science as a derivative of conventional anatomy.

This book focuses on uterine endometrial function and receptivity from multiple perspectives.

This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects.

This book brings together the most up-to-date information on recent research results of leading laboratories on aging science in East Asia, particularly in Japan, Korea, and Hong Kong.

This book is a concise but detailed treatise on the laryngeal nervous system.

This book presents an overview of the recent advances in clinical applications of magnetoencephalography (MEG).

This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors.

This book focuses on actual morphofunctional findings of cells and tissues in living animal organs.

This book presents recent advances in translational research on muscular dystrophy (MD) to physicians and researchers, including cutting-edge research on the disease such as regenerative medicine, next-generation DNA sequencing, and nucleic acid therapies.

This book summarizes the most recent progress in the studies of lipid mediators from the molecular to clinical level and introduces newly created tools for analysis including imaging mass spectrometry.

This book reports the recent progress in gene and cell therapy through the liver and aims to facilitate a comprehensive understanding of the current aspects and future prospects from basic research to clinical therapies.

This book presents a common principle of actions of long noncoding RNAs (lncRNAs) from points of view at the atomic, molecular and cellular levels.

As the number of patients with colitis-associated cancer (CAC) is on the increase, the purpose of this book is to review the latest topics concerning management of the disease.

The aim of this book is to present current views about physical activity and the benefits of physical activity in preventing and ameliorating various health conditions that are of worldwide concern.

This book focuses on (1) sports management, (2) sports economics and policy, and (3) sports humanities.

This book presents the incidence of sports-related injuries, the types of injuries specific to particular sports, and the importance of factors such as age and gender.

This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea.

This book brings together leading international experts to discuss recent advances in functional studies on key proteins and protein complexes involved in each synaptic vesicle phase.

This book covers topics on mechanosensing, mechanotransduction, and actin cytoskeletal dynamics in cell motility.

This book describes the crucial role of "e;zinc signals"e; in biological processes on a molecular and physiological basis, discussing future directions and questions underlying this unique phenomenon.

This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems.

The impaired brain has often been difficult to rehabilitate owing to limited knowledge of the brain system.

This book encompasses major progress and future directions in cytochrome P450 (P450) research.

The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments.