Patch Clamp Methods and Protocols surveys the typical patch clamp applications and advises scientists on identifying problems and selecting the best technique in each instance.
Plants are amazing organisms to study, some are important sources for pharmaceuticals, and others can help to elucidate molecular mechanisms required for a plant's development and its interactions with the biotic or abiotic environment.
The discovery of catalytic RNAs in the mid-1980s marked the beginning of a new era in RNA biology and an ever increasing appreciation of the diverse and critical roles played by this fascinating molecule.
Over the past two decades, spectacular advances have been made in our understanding of the molecular genetics of cancer, leading to the pursuit of identifying genes that, when mutated, result in an increased susceptibility to the disease.
The discovery of wide-spread RNA-based regulation in bacteria has led to new evaluations of the importance of bacterial regulatory RNA in every aspect of bacterial physiology.
In DNA Electrophoresis: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to study DNA using electrophoresis as the major approach.
Since the publication of the first edition, the number of unique heritable mtDNA mutations recognized as being associated with bioenergetic dysfunction, cell death and disease has grown.
Biolistic transfection represents a direct physical gene transfer approach in which nucleic acids are precipitated on biologically inert high-density microparticles (usually gold or tungsten) and delivered directly through cell walls and/or membranes into the nucleus of target cells by high-velocity acceleration using a ballistic device such as the gene gun.
The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes.
The goal of the characterization and discovery of G protein-coupled receptors, arguably the most important class of signaling molecules in humans and other vertebrates, has spawned numerous vital methodologies.
Over the past twenty years, the development of chromatin immunoprecipitation, or ChIP, assays has immensely enhanced the biological significance of the multifaceted DNA-binding proteins.
Despite various difficulties, the field of gene therapy, particularly with regard to cancer, has accumulated a tremendous amount of vital pre-clinical and clinical data.
Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy.
After the generation of genome sequence data from a wide variety of plants, databases are filled with sequence information of genes with no known biological function, and while bioinformatics tools can help analyze genome sequences and predict gene structures, experimental approaches to discover gene functions need to be widely implemented.
The new genetic revolution is fuelled by Deep Sequencing (or Next Generation Sequencing) apparatuses which, in essence, read billions of nucleotides per reaction.
Protocols for Nucleic Acid Analysis by Non-radioactive Probes, Second Edition provides a firm background on the basic preparative protocols required for the analysis of nucleic acids by nonradioactive methods.
Gene therapy offers many conceptual advantages to treat muscle diseases, especially various forms of muscular dystrophies; however, it faces a number of unique challenges, including the need to deliver a therapeutic vector to all muscles throughout the body.
The HLA molecules are important regulators of the immune response through mediating antigen presentation and interaction between key immune mediating cells.
Meet the tiny-but-tough tardigrade and the awe-inspiring blue whale in this illustrated introduction to invertebrates, fish, amphibians, reptiles, birds, and mammals.
This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations.
Channels and transporters are multi-functional proteins that mediate substrate transport and signal transmission and simultaneously act as regulators for other proteins and biosensors for environmental materials.
La morfo-estructura humana, diversa y maravillosa, nos entrega información sobre la forma de las estructuras, los órganos y su interrelación para el adecuado funcionamiento de nuestro organismo, del ejercicio que se realiza, de la maduración física e incluso sobre la calidad alimentaria, siendo una fuente infinita de información para la práctica y la ciencia.
Very Short Introductions: Brilliant, Sharp, Inspiring In this exploration of the concept of the gene, Jonathan Slack looks at the discovery, nature, and role of genes in both evolution and development.
Cardiovascular Endocrinology and Metabolism: Theory and Practice of Cardiometabolic Medicine discusses the close intersection between metabolic disorders and cardiovascular disease, covering the basic science and pathophysiology of disease and the latest research in pharmacological approaches and translational therapeutic options.
The Laboratory Manual for Strength and Conditioning is a comprehensive text that provides students with meaningful lab experiences in the area of strength and conditioning and applied sport science.
The Laboratory Manual for Strength and Conditioning is a comprehensive text that provides students with meaningful lab experiences in the area of strength and conditioning and applied sport science.
With lyrical text, enchanting illustrations, and a beautiful fold-out scene to complete the story, this award-winning picture book takes you on a journey through the seasons and years as you follow a seed's transformation from a seedling to a sapling, then a young tree, until it becomes a large tree with its branches and roots filling the page.
This book provides a detailed overview of the latest developments in the rapidly evolving specialty of Neuro-Oncology arranged in approximately 500 questions arranged in multiple-choice and matching formats.
This book examines the issue of immunity with the signaling pathways it is associated with, which has come to the fore again with the COVID-19 pandemic.
Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology).
L’ouvrage est divisé en deux parties : 1 : L’anatomie macroscopique du système nerveux central permet de revisiter ses parties constitutives avec des images de dissection inhabituelles, rarement montrées dans les ouvrages classiques.
