Pre-clinical medicine: basic sciences

As two of the leading causes of death worldwide, heart disease and stroke represent a clear target for genomic research aimed at deciphering the genes and cellular pathways that underlie cardiovascular disease and creating improved therapies.

Myc controls multiple cellular functions, including cell proliferation, growth, differentiation and death, both directly and indirectly, through its modulation of downstream transcriptional programs.

Transposable elements are used as genetic tools for dissecting the function of a specific gene and elaborating on mechanisms leading to genetic change and diversity, and the evolutionary impact of mobile DNA on the biology and evolution of organism.

This fourth edition reflects the most recent technical advances in DNA-protein interaction research.

This volume discusses the latest technologies used to study all aspects of Fragile-X Syndrome (FXS).

It is now 10 years since the first edition of YAC Protocols was published in 1996.

This volume details protocols that can be used for generation of knockout animals.

Channels and transporters are multi-functional proteins that mediate substrate transport and signal transmission and simultaneously act as regulators for other proteins and biosensors for environmental materials.

Now in a completely revised and expanded fourth edition, including two new chapters, this user-friendly textbook offers a succinct overview of both the medical and surgical management of reproductive disorders, as well as coverage of associated imaging modalities.

Cardiovascular Endocrinology and Metabolism: Theory and Practice of Cardiometabolic Medicine discusses the close intersection between metabolic disorders and cardiovascular disease, covering the basic science and pathophysiology of disease and the latest research in pharmacological approaches and translational therapeutic options.

This well-illustrated, user-friendly text offers a succinct overview of complex surgical sparing management of reproductive pelvic disorders, designed for the reproductive endocrinology and infertility specialist and general gynecologist.

Microarray Technology, Volumes 1 and 2, present information in designing and fabricating arrays and binding studies with biological analytes while providing the reader with a broad description of microarray technology tools and their potential applications.

This volume focuses on RNAs interacting with chromatin and their function.

Activation, inhibition, or destruction of the nervous system or its component parts as a vital tool for the investigation of function has undergone remarkable development; indeed, new approaches have been developed that allow for these actions to be used as therapeutic tools.

In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL).

Transcription Factor Regulatory Methods details various techniques ranging from cutting-edge to general techniques use to study transcription factor regulatory networks.

RNA interference (RNAi), in which RNA silences RNA, is the most recent discovery to revolutionize the study of biology.

This volume provides clear and direct protocols to implement automated Design-Build-Test-Learn (DBTL) into synthetic biology research.

This book will offer for the first time a step-by-step description of the posterior retroperitoneoscopic adrenalectomy, a minimally invasive technique, moving the gold standard of laparoscopic adrenalectomy towards the retroperitoneoscopic approach.

This book discusses many aspects of fetuses and motherhood from fields as wide as sociology and medicine.

This volume provides a collection of protocols for the most common experimental methods used for engineering Yarrowia lipolytica.

This volume details the most important methods used for studying prokaryotic non-coding RNAs and their protein accomplices.

Plants are amazing organisms to study, some are important sources for pharmaceuticals, and others can help to elucidate molecular mechanisms required for a plant's development and its interactions with the biotic or abiotic environment.

Now in its second edition, this atlas serves as an easy-to-use diagnostic guide for the analysis of the human karyotype.

This volume aims at providing state-of-the-art protocols detailing ribosome display, cDNA display, phage display, yeast surface display, and mammalian display.

This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders.

The past decade has seen the emergence of a new field of scientific inquiry at the intersection of phylogenetics and genomics: phylogenomics.

In the past decade, molecular biology has been transformed from the art of cloning a single gene to a statistical science measuring and calculating properties of entire genomes.

Over the past few years, DNA methylation technologies and our knowledge of DNA methylation patterns have been advancing at a breathtaking pace.

Unique textbook presents and integrates dental sciences essential for the practice of dentistryApplied Oral Physiology: The Integration of Sciences in Clinical Dentistry by prosthodontist, biologist, and educator Robin Wilding integrates basic science topics traditionally taught separately, enabling readers to understand the interconnected relationship between the scientific and clinical aspects of dentistry.

This volume provides experimental and bioinformatics approaches related to different aspects of gene expression analysis.

The Visible Monkey is the first trial to obtain high-quality and real-color sectioned images of a rhesus monkey's whole body (intervals, 0.

Animal Endo-SiRNAs: Methods and Protocols presents a variety of approaches to investigate endo-siRNAs.

In this volume expert researchers in the field detail many of the methods which are now commonly used to study RNA.

Innate DNA and RNA Recognition: Method and Protocols presents validated experimental strategies to dissect nucleic acid sensing in-vitro and in-vivo sources.

This completely revised and updated second edition to integrates the many new technologies and insights now available for the diagnosis of genetic diseases.

Despite the many milestones in cystic fibrosis (CF) research, progress towards curing the disease has been slow, and it is increasingly difficult to grasp and use the already wide and still growing range of diverse methods currently employed to study CF so as to understand it in its multidisciplinary nature.

This volume presents the latest protocols for both laboratory andbioinformatics based analyses in the field of marine genomics.

This volume provides readers with an introduction to all the methods and major approaches now being used to study the structural and functional development of the brain.

Chemogenomics aims toward the systematic identification of small molecules that interact with the products of the genome and modulate their biological function.

Synthetic mRNA is an attractive tool for mammalian cell reprogramming that can be used in basic research, as well as in clinical applications.

Smartphone Apps for Health and Wellness helps readers navigate the world of smartphone apps to direct them to those which have had the best medical evidence in obtaining the users' goal.

Great disparities exist between organisms with regard to the relative ease of chromosomal mutagenesis and manipulation.

Patch Clamp Methods and Protocols surveys the typical patch clamp applications and advises scientists on identifying problems and selecting the best technique in each instance.

In the early years of microarray technology, efforts were directed mainly at profiling expressed genes, while recently the microarray platform has been adapted into diverse applications directed toward the investigation of the physical genome.

This volume presents a comprehensive collection of detailed state-of-the-art protocols for gapmer-mediated RNA knockdown from leaders in the field.

Fluorescence in situ Hybridization (FISH) belongs to that special category of well-established molecular biology techniques that, since their inception a few decades ago, have succeeded in keeping a prominent position within the constantly expanding list of laboratory pro- dures for biomedical research and clinical diagnostics.

This volume focuses on cytological, biochemical, and molecular biological methods to identify and examine the function of each nuclear body, with an emphasis on the analysis of long non-coding RNAs.