Pre-clinical medicine: basic sciences

Transmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans.

concerns within the pharmaceutical industry about generating data that might be difficult to interpret in a regulated environment.

Extensive studies have been conducted on the identification, biogenesis, and processing of microRNA (miRNA) as well as research on the exact mechanism by which miRNAs bring about translational silencing of their targets.

This book will be of interest to anyone who wants to use ultrasound to understand human physiology both in the clinical setting and the classroom.

This volume provides an overview about main RNA editing mechanisms, focusing on their functions in physiological as well as pathological conditions.

Environmental genomics seeks to predict how an organism or organisms will respond, at the genetic level, to changes in their external environment.

Ataxia-telangiectasia (A-T) is a rare and severe genetic disorder affecting children.

The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types.

Directed Evolution Library Creation: Methods and Protocols, Second Edition presents user-friendly protocols for both proven strategies and cutting-edge approaches for the creation of mutant gene libraries for directed evolution.

This book entitled "e;Nitric Oxide: From Research to Therapeutics"e; includes the most recent information about the role of Nitric Oxide (NO) in physiology, pathophysiology and its translation to therapeutics.

Pancreatic ductal adenocarcinoma is the fifth leading cause of cancer death in the USA.

This volume contains a comprehensive collection of laboratory protocols used by researchers to analyze varied aspects of non-alcoholic steatohepatitis (NASH).

Immunologists today are interested in all of the diverse cell-types involved in host defense and have a deeper appreciation of the importance of innate immune mechanisms as a first line of protection against pathogens.

This book uniquely explores American cultural values as a factor in maternal health.

Over the last decade Life Science has undergone an accelerated evolution, culminating in the -omics era characterized by the development of a multitude of high throughput methods that are becoming more routinely applied in biochemistry labs.

This volume introduces software used for gene prediction with focus on eukaryotic genomes.

Recent advances in genetics over the last quarter of a century, especially in molecular techniques, have dramatically reduced the cost of determining genetic markers and hence opened up a field of research that is increasingly helping to detect, prevent and/or cure many diseases that afflict humans.

Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals.

Non-coding, inhibitory microRNAs have emerged as important modulators of cellular gene expression, through a process called RNA interference (RNAi).

Cancer Genomics and Proteomics: Methods and Protocols provides a compendium of techniques and applications that will be of profound use to researchers interested in gene identification and function.

In this volume of Methods in Molecular Biology(TM), expert investigators offer comprehensive, complementary, and cutting-edge technologies for studies of gene regulation.

Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models.

This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance.

While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines.

Adenovirus Methods and Protocols, Second Edition, now in two volumes, is an essential resource for adenovirus (Ad) researchers beginning in the field, and an inspirational starting point for researchers looking to branch into new areas of Ad study.

The book focuses on the practical application of articulation and mobilisation techniques with clear explanations and visual support of the techniques.

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Forty years after the term "e;affinity chromatography"e; was introduced, this mode of chromatography remains a key tool in the armory of separation techniques that are available to separation and interaction scientists.

MicroRNAs constitute a particularly important class of small RNAs given their abundance, broad phylogenetic conservation and strong regulatory effects, with plant miRNAs uniquely divulging their ancient evolutionary origins and their strong post-transcriptional regulatory effects.

The concepts of the neuroendocrine system and the immune system emerged more or less simultaneously in the second half of the 20th century.

This manual offers detailed protocols for fluorescence in situ hybridization (FISH) and comparative genomic hybridization approaches, which have been successfully used to study various aspects of genomic behavior and alterations.

In Therapeutic Applications of Ribozymes and Riboswitches: Methods and Protocols, expert researchers in the field provide a complete overview of protocols used in the development of RNA molecule as drugs and drug target.

This volume explores techniques used to study and experiment with Xenopus in order to model or understand human disease.

The first full study of "e;birth figures"e; and their place in early modern knowledge-making.

This updated edition collects cutting-edge techniques used to study neural stem and progenitor cells as well as the brain microenvironment.

This volume detials diverse methodological approaches on the assembly and applications of DNA origami assemblies.

Be prepared for exam day with Barron's.

Share the results of 45 years of front-line medical research!

Este atlas tiene énfasis en las pieles oscuras y presenta una compilación de 355 fotografías dermatológicas.

This classroom-tested textbook is an innovative, comprehensive, and forward-looking introductory undergraduate physics course.

This book highlights the integration of science and imaging and demonstrates how we can teach and learn in a much more accessible, innovative, and engaging way using technology.

Lisa Snowdon is on a mission to spread the word: growing old just means getting better!

Did you know there are critters that are powered by the sun, mammals that lay eggs, and penguins with pink poop?

This third edition of the book offers an up-to-date review of Diabetes Mellitus with a focus on both Micro- and Macrovascular Disease.

This volume detials diverse methodological approaches on the assembly and applications of DNA origami assemblies.

This second edition offers a unique and focused study of the use of ultrasound during the first trimester, a critical time in a fetus' development.

During field- and court-based sports, players are continually required to perceive their environment within a match and select and perform the most appropriate action to achieve their immediate goal within that match instance.

This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms.