Medicinal chemistry

Infectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide.

Drug research has been greatly transformed by the "e;omics revolution"e; and advances in computational tools, combinatorial chemistry, and high throughput screening techniques (HTS).

With significant developments in the areas of chromatography and spectroscopy as well as the unique inherent chemical diversity of natural products, vital in drug research, natural products research has gained new momentum.

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body.

Over the past three decades there have been new developments in therapeutic drug design.

Due to their high specificity and low toxicity profile, peptides have once again become central to the development of new drugs.

Microtubules are essential components of the cytoskeleton, and play critical roles in a variety of cell processes, including cell shaping, intracellular tracking, cell division, and cell migration.

There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences.

The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential.

The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate.

A slow and consistent study of the approaches for drug design can help the foundation for a good scientific intuition.

The ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies.

Das Abweichungsmanagement ist eines von vielen Qualitätssystemen in pharmazeutischen Unternehmen.

Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery.

Les biomarqueurs appliqués à la médecine d'urgence sont en plein essor.

This book addresses the recent trends and clinical research being reported in last 5 to 10 years in the field of nasal drug delivery systems.

The book targets new advances in areas of treatment and drug delivery sciences for tuberculosis.

This detailed volume presents a series of protocols dealing with different aspects of inclusion body (IB) processing, from cloning procedures to purification of refolded product.

This book outlines the use of supramolecules as different pharmaceutical drugs.

This book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations.

The book Function-oriented bioengineered skin equivalents -  continuous development towards complete skin replication aims to provide potential readers with a comprehensive summary of the available information on various in vitro skin models, from historical background to different modeling approaches and their applications.

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In the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability.

This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology.

This book casts new light on the field of oral drug absorption.

This book on "e;Renin-Angiotensin System in Cardiovascular Disease"e; includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects.

This book describes a unique class of secondary metabolites, the mono- and dimeric-naphthylisoquinoline alkaloids.

This book provides a state-of-the-art overview of key areas of subcellular aging research in human cells.

This book focuses on the different compounds (polyphenols, sterols, alkaloids terpenes) that arise from the secondary metabolism of plants and fungi and their importance for research and industry.

this book, the validation of bioanalytical methods is described.

This contributed volume offers a comprehensive discussion on how to design and discover pharmaceuticals using computational modeling techniques.

This book targets new advances in areas of treatment and drug delivery sciences for Malaria.

Practical Pharmaceutics contains essential knowledge on the preparation, quality control, logistics, dispensing and use of medicines.

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY).

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This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design.

Medicinal chemistry is both science and art.

As our understanding of immune mediated chronic inflammatory diseases (IMIDs) grows, it becomes more and more clear that these conditions result from the convergence of a multitude of pathogenic mechanisms whose relative individual contribution is different in different patient subsets.

Medicinal chemistry is both science and art.

The book presents the current state of the art on phytocannnabinoid chemistry and pharmacology and will be of much use to those wishing to understand the current landscape of the exciting and intriguing phytocannabinoid science.

This book reviews recent breakthroughs in anti-cancer drug discovery.

This revised and updated second edition contains multiple microscopic illustrations of all diagnostic entities and ancillary techniques, providing a comprehensive, authoritative guide to all aspects of serous effusions.

This book reviews the current strategies and challenges for the treatment of bacterial, fungal, parasitic and viral infectious diseases in developing countries.

This book explains how to analyze independent data from factorial designs without having to make restrictive assumptions, such as normality of the data, or equal variances.

This book outlines the production of chitooligossacharides and their derivatives and discusses their main biological activities, biomedical applications and their role in disease prevention.

3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use.

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use.

This book provides targeted support for students taking courses at the undergraduate level involving electrochemical methods and voltammetry, precision analytical techniques used in chemical engineering, chemical research and development, and pharmaceutical science.

Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq.