Medicinal chemistry

Over the past three decades there have been new developments in therapeutic drug design.

With significant developments in the areas of chromatography and spectroscopy as well as the unique inherent chemical diversity of natural products, vital in drug research, natural products research has gained new momentum.

This fully updated volume presents a wide range of methods for synthesis, surface modification, characterization and application of nano-sized materials (nanoparticles) in the life science and medical fields, with a focus on drug delivery and diagnostics.

The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential.

This volume explores the latest technological advances and covers all facets of systems medicine with respect to precision medicine.

There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences.

The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate.

This book aims to provide a guide to researchers on how to work with Transient Receptor Potential (TRP) channels, describing current methodologies and protocols, and highlighting the challenges ahead that will require the development of new technologies.

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD).

Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias.

This book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD).

Despite the critical importance of the cerebellum in brain function, the scientific community still lacks effective treatments for most cerebellar ataxias.

Oxygen exists in two gaseous (dioxygen and ozone) and six solid allotropic modifications.

This textbook covers all the essential elements of pharmacokinetics, from basics to applications.

New materials and manufacturing techniques are evolving with the potential to address the challenges associated with the manufacture of medicinal products that will teach new tricks to old drugs.

The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T cell engager ( BITES), Dual Variable Domain ( DVD), Chimeric Antigen Receptor  - Modified Tcells (CART) that are currently being used as therapeutic agents for immunology and oncology disease conditions.

This volume details state-of-the- art methods on computer-aided antibody design.

By examining historical applications of the compounds found in plants, this five-volume series serves as a reference for quality assurance, research, product development, and regulatory guidance of the compounds found in plant-based medicines.

This volume details applications in molecular biological techniques and focuses on applications to determine the involvement of glycans in virus interactions.

Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out.

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry.

Neurology does not include study of the limbic system as this is regarded as more relevant to psychiatry.

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery.

The book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues.

This book deals with the noteworthy advancement in the production of bioactive metabolites from microbes and their pharmacological significance.

This brief explores recent progress in the area of polysaccharides and their composites and nanocomposites.

This volume is devoted to compounds in which the spiro centre is part of a pyranoid or furanoid or an iminosugar ring.

This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD.

This book has been assembled with the hope of being an authoritative, comprehensive, conceptually sound and highly informative compilation of recent advances describing the concepts of bioengineering in the field of microbiology.

This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases.

This book presents an authoritative review of the most significant findings about all the epigenetic targets (writers, readers, and erasers) and their implication in physiology and pathology.

Translational medicine addresses the gap between research and the clinical application of new discoveries.

This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field.

From Aspirin to Viagra, insulin to penicillin, and vaccines to vitamin supplements, drugs have become part of our everyday lives.

This book provides the first comprehensive overview of the emerging field of interdisciplinary salivary bioscience.

Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients.

Non-linear phenomena pervade the pharmaceutical sciences.

This book provides a modern and easy-to-understand introduction to the chemical equilibria in solutions.

This book offers an overview of the statistical methods used in clinical and observational vaccine studies.

This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design.

This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer.

Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects.

Particularly in healthcare fields, there is growing movement away from traditional lecture style course towards active learning and team-based activities to improve learning and build higher level thinking through application of complex problems with a strong foundation of facts and data.

This book presents the applications of ion-exchange materials in the biomedical industries.

Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq.

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This volume comprises three reviews.

Currently there are no process validation (PV) textbooks addressing the lifecycle concepts (Stage 1, 2, 3).

The first contribution summarizes current trends in research on medicinal plants in Mexico with emphasis on work carried out at the authors' laboratories.

This reference work provides a comprehensive review of cell and tissue differentiation and its role in the formation of specific secondary metabolites.