Medicinal chemistry

Defining the Lung Cancer Problem 1 Lung cancer is the leading cause of cancer death in the world.

Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation.

This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms.

Despite wide recognition as a serious public health problem, anaphylaxis and hypersensitivity reactions remain under-recognized and under-diagnosed.

As sites of action for drugs used to treat schizophrenia and Parkinson's disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders.

This book offers a comprehensive and authoritative review of the biological and ecological roles played by specialized metabolites (secondary metabolites) in the life cycle of plants, and it also covers the latest biotechnological advances in metabolite production and various industrial applications.

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application.

I want to thank all who contributed to this first edition for their hard work and professionalism, and especially for their patience.

Bioarrays: From Basics to Diagnostics provides an integrated and comprehensive collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine.

A team of expert investigators and clinical researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients.

Welcome to Dopeworld.

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function.

The aim of this book is to present a range of analytical methods that can be used in formulation design and development and focus on how these systems can be applied to understand formulation components and the dosage form these build.

This title is a comprehensive text that addresses key aspects of nanomedicine such as properties occurring at the nanoscale that have unique medical effects, great molecular knowledge of the human body and disease processes, and apparent clinical translation as opposed to narrow insufficient texts that address only a few topics and attempt to "e;rebrand"e; established drug delivery.

This book sheds new light on the molecular mechanisms that generate circadian rhythms.

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters.

This book covers in detail the mechanisms for how energy is managed in the human body.

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery.

"e;Biobetters: Protein Engineering to Approach the Curative"e; discusses the optimization of protein therapeutic products for treatment of human diseases.

This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.

This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research.

This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs.

This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release.

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines.

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties.

This comprehensive volume provides an update on the current state of pharmacometrics in drug development.

This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence.

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence.

Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all.

This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth.

'It is indeed the merit of Dr.

John E.

Only four short decades ago, the control of insect pests by means of chemicals was in its early infancy.

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY).

More than 100 years ago, Dr Casimir Funk suggested the existence of a family of organic substances that are essential for life and thus introduced the concept of "e;vital amines"e; as essential nutrients with a specific action, requiring only minute amount with the power to cure a specific disease.

In Cannabis Is Medicine, medical cannabis specialist Bonni Goldstein, MD, explains the science behind the use of this amazingly therapeutic plant and describes in easy-to-understand detail the recently discovered endocannabinoid system, involved in almost every human physiological process.

Through the contributions of global experts, this book meets the growing need to understand the implementation and development of pharmaceutical care.

The recent surge of interest in recombinant DNA research is understandable considering that biologists from all disciplines, using recently developed mo- lecular techniques, can now study with great precision the structure and regulation of specific genes.

Our motivation for putting together this book was the need for a single source reference that could be used as an introduction to cell-mediated cytotoxicity for newcomers to this field, such as students and fellows beginning work in our laboratories.

Pancreatic a-cell biophysics has undergone a veritable informa- tion explosion in the past two years.

One day, in a moment of weakness, I fell prey to the temptation to organize and edit this volume on the mechanism of insulin action.

Prefaces tend to be platitudinous and unconducive to perusal.

This book is the outcome of a meeting held in Davos, Switzerland, February 7-12, 1982 focused primarily on mononuclear phagocytes and on natural killer (NK) cells.

With the advancement in medicinal chemistry and material science, several highly specific, biocompatible and non-toxic therapeutic agents have been discovered and successfully applied for various clinical applications.

The annual meeting of the Perinatal Biochemical Group of the Spanish Biochemical Society held in Madrid on December 15-16, 1989, provided an excellent opportunity to bring together a group of distinguished investigators both from Spain and from abroad with a common interest in developmental endocrinology and biochemistry.