Medicinal chemistry

The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs.

The cost of drug development is increasing, and investment returns are decreasing.

The cost of drug development is increasing, and investment returns are decreasing.

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety, and stability of the final medicinal product.

Implantable technologies allow for a sustained control over the release of pharmaceuticals into the bloodstream thereby achieving a controlled concentration with the potential to minimise side-effects while increasing patient compliance.

Implantable technologies allow for a sustained control over the release of pharmaceuticals into the bloodstream thereby achieving a controlled concentration with the potential to minimise side-effects while increasing patient compliance.

Alzheimer's disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition.

Alzheimer's disease is an increasingly common form of dementia and despite rising interest in discovery of novel treatments and investigation into aetiology, there are no currently approved treatments that directly tackle the causes of the condition.

This glossary expands upon the Comprehensive Glossary of Terms Used in Toxicology.

This glossary expands upon the Comprehensive Glossary of Terms Used in Toxicology.

New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions.

A classic in the literature of herbal medicine, this book explains in simple terms the commonly occurring chemical constituents of medicinal plants, and how these react with the human body.

A classic in the literature of herbal medicine, this book explains in simple terms the commonly occurring chemical constituents of medicinal plants, and how these react with the human body.

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization.

Photoaging results from chronic exposure to UV radiation and is an increasingly common clinical feature, with an aging population the clinical burden is likely to increase despite advances in our understanding of the pathology and development of improved treatments.

Antibody-drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery.

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions.

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients.

Coffee is one of the most popular drinks in the world but what are the health advantages or disadvantages from consuming it?

New genomic information has revealed the crucial role that protein-protein interactions (PPIs) play in regulating numerous cellular functions.

Metal-based anticancer drugs are among the most successful therapeutic agents, as evidenced by the frequent prescription of selected platinum and arsenic compounds to patients.

Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization.

From pathology to treatment, MicroRNAs in Diseases and Disorders highlights the role of microRNAs (miRNAs) in the development and progression of a variety of diseases, including cancer, neurological disease, endocrine disease and autoimmune disease, and underscores the utilization of miRNA targets in the treatment of these conditions.

Photoaging results from chronic exposure to UV radiation and is an increasingly common clinical feature, with an aging population the clinical burden is likely to increase despite advances in our understanding of the pathology and development of improved treatments.

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry.

Sight loss and blindness is a very prevalent cause of disability.

Oncogenic transcription factors are an increasingly important target for anticancer therapies.

Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology.

Coffee is one of the most popular drinks in the world but what are the health advantages or disadvantages from consuming it?

The formation of disulphide bonds is probably the most influential modification of proteins.

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product.

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules.

Molecular imaging of drugs or drug carriers is a valuable tool that can provide important information on spatiotemporal distribution of drugs, allowing improved drug distribution at target sites.

Sight loss and blindness is a very prevalent cause of disability.

The formation of disulphide bonds is probably the most influential modification of proteins.

Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry.

There have been remarkable advances towards discovering agents that exhibit selectivity and sequence-specificity for DNA, as well as understanding the interactions that underlie its propensity to bind molecules.

Antibody-drug conjugates (ADCs) represent one of the most promising and exciting areas of anticancer drug discovery.

Synthetic chemistry plays a central role in many areas of chemical biology; utilising recent case studies, the goal of Chemical and Biological Synthesis is to highlight the full impact that the preparation of novel reagents can have in chemical biology.

Molecular imaging of drugs or drug carriers is a valuable tool that can provide important information on spatiotemporal distribution of drugs, allowing improved drug distribution at target sites.

Strategic decision-making focusing on economics is the fundamental requirement to generate efficiency and improve productivity in any manufacturing environment.

This book takes readers on a journey from the very fundamental and chemical beginnings of amino acids on Earth to their role in human metabolism.

Formulation is a key step in the drug design process, where the active drug is combined with other substances that maximise the therapeutic potential, safety and stability of the final medicinal product.

Oncogenic transcription factors are an increasingly important target for anticancer therapies.

Since the discovery and successful deployment of salvarsan to treat syphilis, as well as cisplatin as a cancer drug, the field of metallodrugs has been flourishing.

This definitive guide provides readers with an overview of multifunctional nanoparticles, delving into their novel synthesis methods, unique properties, and diverse applications in therapy, biology, and pharmacy.

Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies.

The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation.

For over 3,000 years, ashwagandha has held a prominent place in Ayurveda and Unani, two of India's ancient medicinal traditions.

Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate.