Medicinal chemistry

Defining the Lung Cancer Problem 1 Lung cancer is the leading cause of cancer death in the world.

Membrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation.

This succinct resource provides an ideal balance of the biology and practical therapeutic strategies for classic and non-classic BCR-ABL-negative myeloproliferative neoplasms.

Despite wide recognition as a serious public health problem, anaphylaxis and hypersensitivity reactions remain under-recognized and under-diagnosed.

In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application.

I want to thank all who contributed to this first edition for their hard work and professionalism, and especially for their patience.

Bioarrays: From Basics to Diagnostics provides an integrated and comprehensive collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine.

A team of expert investigators and clinical researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients.

Edited by a renowned international expert in the field, Nuclear Medicine Physics offers an up-to-date, state-of-the-art account of the physics behind the theoretical foundation and applications of nuclear medicine.

Welcome to Dopeworld.

This book reviews the evolving field of epigenetics and its implications for drug discovery and precision medicine.

Nature is an attractive source of therapeutic and preventive compounds, and with such chemical diversity found in millions of species of plants, over 60% of currently used anticancer agents are derived from natural sources.

The term phytomedicine was coined by French physician Henri Leclerc in 1913.

Cannabis sativa is best known as the source of marijuana, the worlds most widely consumed illicit recreational drug.

There is a compelling need for new drugs and efficient treatments against mosquito-borne diseases.

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach.

Antimicrobials: Synthetic and Natural Compounds summarizes the latest research regarding the possibilities of the most important natural antimicrobial compounds derived from various plant sources containing a wide variety of secondary metabolites.

A brief history of drug design presented to make clear that there are fashions in this important field and that they change rather rapidly.

Since the discovery of Aquaporin-1 (AQP1) as a water channel, many studies have revealed the importance of aquaporins in mammalian physiology and pathophysiology as well as plant and microbial biology.

The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function.

This title is a comprehensive text that addresses key aspects of nanomedicine such as properties occurring at the nanoscale that have unique medical effects, great molecular knowledge of the human body and disease processes, and apparent clinical translation as opposed to narrow insufficient texts that address only a few topics and attempt to "e;rebrand"e; established drug delivery.

This book sheds new light on the molecular mechanisms that generate circadian rhythms.

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters.

This book covers in detail the mechanisms for how energy is managed in the human body.

Authored by leading experts from academia, users and manufacturers, this book provides an authoritative account of the science and technology involved in multiparticulate drug delivery systems which offer superior clinical and technical advantages over many other specialized approaches in drug delivery.

"e;Biobetters: Protein Engineering to Approach the Curative"e; discusses the optimization of protein therapeutic products for treatment of human diseases.

This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.

This detailed volume addresses key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release.

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines.

This authoritative volume provides a contemporary view on the latest research in molecules with optimal drug-like properties.

This comprehensive reference provides an in-depth discussion on state-of-the-art regulatory science in bioequivalence.

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence.

Until the 1990s, it was generally accepted that medicines were first developed for adults and their use in children was investigated later, if at all.

This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth.

'It is indeed the merit of Dr.

John E.

Only four short decades ago, the control of insect pests by means of chemicals was in its early infancy.

The disability-adjusted life year (DALY) is a generic measure of health effect that can be used in cost-effectiveness analysis as an alternative to the quality-adjusted life year (QALY).

Nucleosides exhibit a broad spectrum of biological activity that generally results from their ability to inhibit specific enzymes.

This text traces developments in rational drug discovery and combinatorial library design with contributions from 50 leading scientists in academia and industry who offer coverage of basic principles, design strategies, methodologies, software tools and algorithms, and applications.

"e;Addresses the key topic in combinatorial synthesis--how to optimize the quality of a combinatorial library--by determining the usefulness of synthesized compunds, the reliability of biological assay results, and analyzing acadmic and industrial applications, real-world examples, and case studies of successful and unsuccessful technologies.

This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments.

Opioids such as morphine, codeine, and oxycodone are extracts or analogs isolated from a single source: the opium poppy.

In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design.

Modern Medicine: Biomedical Devices, Medical Gases, Radiopharmaceuticals, New Drug Discovery, Volume 2 discusses the procedures of drug approval and regulatory requirements that must be met according to the United States Food and Drug Administration (FDA), the European Medical Agency (EMA), and the Central Drug Standard Control Organization (CDSCO).