Medicinal chemistry

As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity.

Nanotechnology in Dermatology is the first book of its kind to address all of the important and rapidly growing aspects of nanotechnology as it relates to dermatology.

Macromolecular (specifically peptide-based) drugs could potentially be highly effective medicines.

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues.

Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically.

The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community.

This book focuses on the adoption of medical technology in the developing world, and the role that can be played by new biomaterials.

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking.

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry.

This book is devoted to the graphics of patient data: good graphs enabling straight forward and intuitive interpretation, efficient creation, and straightforward interpretation.

This book summarizes present knowledge of different mechanisms involved in the development of positive and negative consequences of cardiac adaptation.

This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better.

This Brief defines competitive intelligence (CI) as a tool for making investment decisions within the pharmaceutical industry.

Performing in a high G environment is extremely demanding on the body: pulling G forces blood to the body's extremities, putting the pilot, astronaut or driver at risk of G-Induced Lack of Consciousness (G-LOC).

"e;Space Pharmacology"e; is a review of the current knowledge regarding the use of pharmaceuticals during spaceflights.

Increasing demand for and awareness of the applications of nanotechnology in medicine has resulted in the emergence of a new fast-growing multidisciplinary area - nanomedicine.

This Brief discusses key statistical concepts that facilitate the inferential analysis of data collected from a group of individuals participating in a pharmaceutical clinical trial, the estimation of their clinical significance in the general population of individuals likely to be prescribed the drug if approved, and the related decision-making that occurs at both the public health level (by regulatory agencies when deciding whether or not to approve a new drug for marketing) and the individual patient level (by physicians and their patients when deciding whether or not the patient should be prescribed a drug that is on the market).

This volume is intended to provide the reader with a breadth of understanding regarding the many challenges faced with the formulation of poorly water-soluble drugs as well as in-depth knowledge in the critical areas of development with these compounds.

This book was designed as a reference tool for pharmacists involved in the treatment of patients with infections.

Long acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability.

The aim and scope of this book is to highlight the sources, isolation, characterization and applications of bioactive compounds from the marine environment and to discuss how marine bioactive compounds represent a major market application in food and other industries.

Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series.

The last 10 years have seen a seismic shift in therapeutic product development and testing.

Pharmaceutical manufacture is very exacting - for example, drugs must be uniform in size, shape, efficacy, bioavailability, and safety.

The main theme of Part B is the description of synthetically useful reactions and the illustration of their application.

In tracing their origin and their fate, the beginning and the end of their environment, humans have often been guided by curiosity.

When a dose of drug is administered, three main phases of drug action may be distingushed.

This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis.

In summary, there are many animal models that are useful in selecting new antiarrhythmic drugs.

The purpose of this book is to focus attention on recent developments in steroid and sterol hormone action.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy?

Our understanding of biological communication has grown significantly during the past decade.

The blurring of boundaries between hitherto distinct scientific disciplines, technologies or markets is a common and powerful phenomenon.

Artificial organs may be considered as small-scale process plants, in which heat, mass and momentum transfer operations and, possibly, chemical transformations are carried out.

The world is beset by a pandemic of obesity and type 2 diabetes and the need for new drugs is startlingly clear; recent years have seen a huge increase in research activity to fill this gap.

This book provides the perspectives of many different stakeholders in the biopharmaceuticals field, who share knowledge, challenges, and solutions in an ever-shifting career landscape.

This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs.

The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago.

This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods.

Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology.

"e;About 25 years ago, Mosmann & Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation.

Calcium-Sensing Receptor provides an overview of various aspects of the calcium receptor's biochemistry, physiology and pathophysiology that is suitable both for those who have been working in the field of Ca2+0-sensing as well as those who are new to this discipline.

Microscopy plays an integral role in the research and development of new medicines.

The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams.