Since the discovery some 15 years ago of benzodiazepinemodulatory sites associated with GABA A receptors, greateffort has gone into understanding their molecularpharmacology and into developing new anxiolytic drugs thatinteract selectively with them.
Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches utilized intracellularly in biological systems.
Recent advances in molecular biology have shown GTPases and phosphoproteins to be the paramount molecular switches uti- lized intracellularly in biological systems.
Major advances have been made in the understanding of the molecular mechanisms of atherosclerosis, the disease that still affects more than 50 percent of the population in the highly industrialized countries.
Advances in molecular biology describing important enzyme systems involved in drug conjugation and deconjugation reactions and recent work indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds are reviewed comprehensively.
It has been almost 20 years since the discovery by Kohler and Milstein of the technology to produce monoclonal antibodies (MAbs), a discovery that promised revolutionary changes in research, clinical diagnosis and human therapy.
This book contains the papers from invited lecturers as well as selected contributions presented at the 6th International Meeting on Clinical Pharmacology in Psychiatry (I.
The intriguing complexity, precision, and regulation of the wide range of biologi- cal processes is determined by intricate mechanisms of molecular recognition.
The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer.
The European School of Oncology came into existence to respond to a need for information, education and training in the field of the diagnosis and treatment of cancer.
Cell transplantation to the brain and spinal cord is awell-established research tool for studies on cellular andmolecular mechanisms, but can it be developed into a usefultherapuetic approach in human neurological disorders?
Since 1961, when pain therapy was introduced by Bonica, the-re have been world-wide efforts to establish basic regimensfor the treatment of chronic pain.
In this volume the impact of cell culture models ondermatological research is discussed by scientists frommedicine, physiology, biology, pharmacology,and pharmacy.
In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system.
Since the thalidomide (Contergan) tragedy about 30 years agothe induction of prenatally-induced morphological orfunctional defects has been an area of extensive research.
Recent years have witnessed an explosion of knowledge lea-ding to a molecular understanding of the mechanisms of ac-tion of calcium on excitation and contraction coupling andits role in the regulation of contractility.
In 1957 Otto SCHAUMANN, one of the pionieers in pharmacological research on morphine and the first to prepare synthetic opiates, presented a mono- graph entitled "e;Morphin und morphiniihnliche Verbindungen"e; as Volume 12 of the Handbook of Experimental Pharmacology.
Advances in Controlled Clinical Inhalation Studiesrepresents scientific work presented at the 3rdInternational Inhalation Symposium held 1991 in Hannover,FRG.
Studies on the colon not only serve medical interest or clinical purposes, but are also a highly interesting subject of comparative physiology, from which we can learn much about the basic principles in physiology.
