Pharmacology

Published in the series Headache, endorsed by the European Headache Federation, this is the first book on the novel synthetic treatment of migraine with ditans (lasmiditan) and gepants (atogepant, ubrogepant, rimegepant, vazegepant).

This book describes the discovery of molecules from unexploited extreme marine environments, and presents new approaches in marine genomics.

This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology.

Rapidly growing interest in the role of organic cation transporters (OCTs) and plasma membrane monoamine transporter (PMAT) in central monoamine homeostasis makes this book especially timely, given its thematic alignment with the role of OCTs and PMAT in CNS.

Now in its updated second edition, this book describes emerging chiral environmental pollutants and their importance in environmental and human toxicology, as well as enantiomer selective separation and analytical methods.

This new edition presents a fully-updated and expanded look at current Good Manufacturing Practice (cGMP) for cell therapy products.

This third edition of the highly successful textbook, acclaimed for its comprehensiveness, accuracy, and excellent illustrations and photographs now comes with updated coverage plus numerous didactical improvements:The number of figures has notably increased, with about one third of them now presented in color.

This graduate textbook serves as a highly readable guide on vaccines and vaccination in infants, children and adolescents from an European perspective.

The growing importance of glycobiology and carbohydrate chemistry in modern biotechnology and the pharmaceutical industry makes accurate carbohydrate analysis indispensable.

In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures.

This book updates in detail the microbial pathogenesis of various important pathogens, including HIV-1, MERS, SARS-CoV-2, Mycobacterium and Plasmodium.

This book gives an overview of therapeutic drug monitoring (TDM) and its clinical application.

This significantly revised fourth edition provides a practically orientated guide to interactions associated with antiseizure medications.

This book has a broad scope and provides a comprehensive overview of the most up-to-date knowledge of the plant genus Baccharis.

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology.

This book addresses the highly relevant subject of emerging pollutants, which are especially alarming since most of the available treatment technologies are unable to degrade them.

The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments.

This volume describes the pathogenesis and pathophysiology of several pulmonary diseases as well as their treatment.

The book covers the area of 'Nanotoxicology' but primarily from the point of view of nanotoxicology at the interface with other disciplines including human toxicology; environmental toxicology; characterization, dose and transformations; regulation; public and elite group perceptions; and interactions with innovation.

This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices.

This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology.

Reflux is an important factor in many different lung diseases and its manifestations are under recognised.

This book is a compilation of some of the most remarkable contributions made by scientists currently working in Latin America to the understanding of virus biology, the pathogenesis of virus-related diseases, virus epidemiology, vaccine trials and antivirals development.

There are few publications about drug interactions in chemotherapy and even less about pediatric oncology treatment.

This book provides an update on recent clinical practice and an in-depth view of selected topics relevant to hospital medicine.

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL).

The dangerous decline in vaccinations in many developed countries is at the heart of a lively debate that confirms how important the subject is today.

This volume offers a comprehensive overview of basic and applied aspects of Staphylococcus aureus, which is one of the most important human pathogens.

Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants.

This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application.

This is the second edition of a well-received book that reflects the state of the art in cancer medical therapies and their side-effects, including immunotherapy and chemotherapeutic drugs.

The first of its kind for budget-impact analysis, this comprehensive guide provides clear and concise instructions for evaluating the impact that new pharmaceuticals will have on the budget for a specific jurisdiction.

This book provides a detailed summary of the therapeutic benefits of natural extracts from medicinal plants, mushrooms, algae, fungi and sponges and their role in the prevention and treatment of obesity and diabetes, offering readers a solid introduction to obesity and diabetes as well as current treatment models.

This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 16 pain categories with an evidence-based literature review on each pain disorder, illustrative figures showing anatomy and techniquesIntroductory chapters cover basic information about the mechanism, function and the analgesic effects of the BoNTs based on the data derived from animal studies.

Cellular trafficking is only recently identified as a site for therapeutic intervention.

This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy.

This third and final volume in the "e;Ion Transport in Tumor Biology"e; collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins.

This book covers all aspects of hypersensitivity to drugs, providing practical information for non-specialist physicians as well as addressing issues of interest to practitioners in different specialties and presenting the expert knowledge required by specialist allergists and immunologists.

This book provides a comprehensive coverage of the state of the art in precision medicine in stroke.

This book is an international effort to standardize the language, terms, and methods used in ocular toxicology.

Tamoxifen is a pioneering medicine for the treatment and prevention of breast cancer.

Drug resistance is a fundamental factor in treatment failure in diseases like leishmaniasis, although additional factors also play a role in this phenomenon.

In a rapidly progressing field, Botulinum Toxin Therapy provides both clinicians and basic researchers with the latest science on the structure and function of botulinum toxins and the use of these toxins to treat a wide variety of diseases.

This book reviews advanced techniques for the determination of pesticide residues, with focus on extraction, detectors and cleaning protocols.

The over-arching goal of this volume is to help infertility practitioners evaluate and manage their patients with poor semen quality.

This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging.

Volume Two advances the exploration of the fundamental principles of oxidative stress and toxicity on male (and female) reproduction.

Hypertension: from basic research to clinical practice"e; contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world.

Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem.